Journal
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
Volume 5, Issue 3, Pages -Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/NXI.0000000000000449
Keywords
-
Categories
Funding
- Federal Ministry of Education and Research (BMBF)
- Santhera
- Carlos III Health Institute [JR/00008, PI/16/00005]
- Teva
- OCTiMS study
- Novartis
- NIH
- Biomedical Research Centre, based at Moorfields Eye Hospital
- NHS Foundation Trust
- UCL Institute of Ophthalmology
- Bayer
- Biogen
- Sanofi-Aventis/Genzyme
- Merck Serono
- Alexion
- Chugai
- MedImmune
- Shire
- German Research Council
- Werth Stiftung of the City of Cologne
- German Ministry of Education and Research
- Arthur Arnstein Stiftung Berlin
- EU FP7 Framework Program
- Arthur Arnstein Foundation Berlin
- Guthy Jackson Charitable Foundation
- US National Multiple Sclerosis Society
- Instituto de Salud Carlos III
- European Commission
- National MS Society
- Fundacion Maraton TV3
- GAEM Foundation
- Novartis Pharma OCTIMs
- Inception Sciences SRA
- NINDS
- NIA
- Sherak Foundation
- Hilton Foundation
- Sanofi-Genzyme
- University of Zurich
- Betty and David Koetser Foundation for Brain Research
- Swiss Multiple Sclerosis Society
Ask authors/readers for more resources
Objective To evaluate the inter-rater reliability of semiautomated segmentation of spectral domain optical coherence tomography (OCT) macular volume scans. Methods Macular OCT volume scans of left eyes from 17 subjects (8 patients with MS and 9 healthy controls) were automatically segmented by Heidelberg Eye Explorer (v1.9.3.0) beta-software (Spectralis Viewing Module v6.0.0.7), followed by manual correction by 5 experienced operators from 5 different academic centers. The mean thicknesses within a 6-mm area around the fovea were computed for the retinal nerve fiber layer, ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer, outer plexiform layer (OPL), and outer nuclear layer (ONL). Intraclass correlation coefficients (ICCs) were calculated for mean layer thickness values. Spatial distribution of ICC values for the segmented volume scans was investigated using heat maps. Results Agreement between raters was good (ICC > 0.84) for all retinal layers, particularly inner retinal layers showed excellent agreement across raters (ICC > 0.96). Spatial distribution of ICC showed highest values in the perimacular area, whereas the ICCs were poorer for the foveola and the more peripheral macular area. The automated segmentation of the OPL and ONL required the most correction and showed the least agreement, whereas differences were less prominent for the remaining layers. Conclusions Automated segmentation with manual correction of macular OCT scans is highly reliable when performed by experienced raters and can thus be applied in multicenter settings. Reliability can be improved by restricting analysis to the perimacular area and compound segmentation of GCL and IPL.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available