Journal
PLANT CELL
Volume 29, Issue 6, Pages 1373-1387Publisher
OXFORD UNIV PRESS INC
DOI: 10.1105/tpc.16.00579
Keywords
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Funding
- National Natural Science Foundation of China (NSFC) [31430010]
- National Basic Research Program of China (973 Program) [2014CB943500]
- National Program for Support of Top-Notch Young Professionals
- State Key Laboratory of PlantGenomics
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The homeodomain transcription factor WUSCHEL (WUS) defines the shoot stem cell niche, but the mechanisms underlying the establishment of WUS expression remain unclear. Here, we show that cytokinin signaling precedes WUS expression in leaf axils and activates WUS expression de novo in the leaf axil to promote axillary meristem initiation. Furthermore, type-B Arabidopsis response regulator proteins, which are transcriptional activators in the cytokinin signaling pathway, directly bind to the WUS promoter and activate its expression. Finally, we show that cytokinin activation of WUS in the leaf axil correlates with increased histone acetylation and methylation markers associated with transcriptional activation, supporting the fact that WUS expression requires a permissive epigenetic environment to restrict it to highly defined meristematic tissues. Taken together, these findings explain how cytokinin regulates axillary meristem initiation and establish a mechanistic framework for the postembryonic establishment of the shoot stem cell niche.
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