Journal
PLANT AND CELL PHYSIOLOGY
Volume 58, Issue 12, Pages 2202-2216Publisher
OXFORD UNIV PRESS
DOI: 10.1093/pcp/pcx155
Keywords
Autoimmune; CHR5; Chromatin remodeling; Immunity; Nucleosome occupancy; SNC1
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Funding
- National Science Foundation of China [31500215]
- National Science Foundation of the USA [IOS-1353738]
- Fundamental Research Funds for the Central Universities [KJQN201631]
- Jiangsu Collaborative Innovation Center for Modern Crop Production
- China Scholarship Council
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1353738] Funding Source: National Science Foundation
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ATP-dependent chromatin-remodeling factors use the energy of ATP hydrolysis to alter the structure of chromatin and are important regulators of eukaryotic gene expression. One such factor encoded by CHR5 (ChromatinRemodeling Factor 5) in Arabidopsis (Arabidopsis thaliana) was previously found to be involved in regulation of growth and development. Here we show that CHR5 is required for the up-regulation of the intracellular immune receptor gene SNC1 (SUPPRESSOR OF npr1-1, CONSTITUTIVE1) and consequently the autoimmunity induced by SNC1 up-regulation. CHR5 functions antagonistically with another chromatin-remodeling gene DDM1 (DECREASED DNA METHYLATION 1) and independently with a histone mono-ubiquitinase HUB1 (HISTONE MONOUBIQUITINATION 1) in SNC1 regulation. In addition, CHR5 is a positive regulator of SNC1-independent plant immunity against the bacterial pathogen Pseudomonas syringae. Furthermore, the chr5 mutant has increased nucleosome occupancy in the promoter region relative to the gene body region at the whole-genome level, suggesting a global role for CHR5 in remodeling nucleosome occupancy. Our study thus establishes CHR5 as a positive regulator of plant immune responses including the expression of SNC1 and reveals a role for CHR5 in nucleosome occupancy which probably impacts gene expression genome wide.
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