Journal
OPEN DENTISTRY JOURNAL
Volume 12, Issue -, Pages 455-465Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1874210601812010455
Keywords
Immune suppression; Tumor Microenvironment (TME); T-Regulatory cell (Treg); Myeloid Derived Suppressor Cell (MDSC); Cancer-Associated Fibroblasts (CAFs); Oral malignancy
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Funding
- Japan Society for the Promotion of Science KAKENHI [17K11891]
- Grants-in-Aid for Scientific Research [17K11891] Funding Source: KAKEN
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Introduction: In order to survive, cancers control immune systems and evade immune detection using mediators consisting of immune checkpoint molecules and cellular systems associated with immune suppression. Methodology: During the development of cancer and chronic infections, the immune checkpoints and cellular components including regulatory T cells, myeloid derived suppressor cells and cancer associated fibroblasts are often enhanced as a mechanism of immune subversion and have therefore become very important therapeutic targets. Conclusion: In this review, we will discuss the complexity of immune-suppressive mechanisms in the tumor milieu of cancers, including oral malignancy.
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