Journal
PLACENTA
Volume 60, Issue -, Pages 36-39Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2017.09.013
Keywords
Micro-CT; Optimisation; Perfusion; Contrast
Funding
- Department of Health NIHR Biomedical Research Centre's funding scheme
- National Institute for Health Research (NIHR) Clinician Scientist Fellowship [NIHR-CS-012-002]
- NIHR Senior Investigator award
- Great Ormond Street Children's Charity
- Great Ormond Street Hospital NIHR Biomedical Research Centre [ORMBRC-2012-1]
- National Institute for Health Research (NIHR)
- Great Ormond Street Hospital Childrens Charity [V0117] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0513-10046, NIHR-CS-012-002] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [ormbrc-2012-1] Funding Source: National Institutes of Health Research (NIHR)
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Micro-CT provides 3D volume imaging with spatial resolution at the micrometre scale. We investigated the optimal human placenta tissue preparation (contrast agent, perfusion pressure, perfusion location and perfusion vessel) and imaging (energy, target material, exposure time and frames) parameters. Microfil (Flow Tech, Carver, MA) produced better fill than Barium sulphate (84.1%(+/- 11.5%) vs70.4%(+/- 18.02%) p = 0.01). Perfusion via umbilical artery produced better fill than via chorionic vessels (83.8%(+/- 17.7%) vs78.0%(+/- 21.9%), p < 0.05), or via umbilical vein (83.8%(+/- 16.4%) vs69.8%(+/- 20.3%), p < 0.01). Imaging at 50 keV with a molybdenum target produced the best contrast to noise ratio. We propose this method to enable quantification and comparison of the human fetoplacental vascular tree. (c) 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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