Journal
PIGMENT CELL & MELANOMA RESEARCH
Volume 31, Issue 3, Pages 423-431Publisher
WILEY
DOI: 10.1111/pcmr.12677
Keywords
beta-catenin; histopathology; Ink4a; melanocyte; melanoma; melanoma model; Pten; Ras; transgenic mice
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Funding
- Institut National Du Cancer
- Ligue Contre le Cancer - comite de l'Oise
- ITMO Cancer
- ANR Labex CelTisPhyBio [ANR-11-LBX-0038, ANR-10-IDEX-0001-02 PSL]
- INCa
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Genetically engineered mouse models offer essential opportunities to investigate the mechanisms of initiation and progression in melanoma. Here, we report a new simplified histopathology classification of mouse melanocytic lesions in Tyr::NRAS(Q61K) derived models, using an interactive decision tree that produces homogeneous categories. Reproducibility for this classification system was evaluated on a panel of representative cases of murine melanocytic lesions by pathologists and basic scientists. Reproducibility, measured as inter-rater agreement between evaluators using a modified Fleiss' kappa statistic, revealed a very good agreement between observers. Should this new simplified classification be adopted, it would create a robust system of communication between researchers in the field of mouse melanoma models.
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