Journal
PHYTOCHEMISTRY REVIEWS
Volume 16, Issue 3, Pages 527-533Publisher
SPRINGER
DOI: 10.1007/s11101-017-9500-x
Keywords
Anticancer; Dihydrochalcones; Phenolic compound; Phloretin
Categories
Funding
- Spanish Ministry of Health, Social Services and Equality [CIBEROBN - CB12/03/30038]
Ask authors/readers for more resources
Dihydrochalcones are a class of secondary metabolites, whose demand in biological and pharmacological applications is rapidly growing. Phloretin is one of the best known and abundant dihydrochalcone characterized by the presence of 2,6-dihydroxyacetophenone pharmacophore. It is a versatile molecule with anticancer, antiosteoclastogenic, antifungal, antiviral, anti-inflammatory, antibacterial and estrogenic activities and able to increase the fluidity of biological membranes and penetration of administered drugs. In this review we have performed a critical evaluation of available literature as far as phloretin beneficial effects and activation/block of intracellular signal cascade are of concern. In addition, we supply useful information on its chemical properties, sources and bioavailability.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available