Journal
PHYTOCHEMISTRY LETTERS
Volume 22, Issue -, Pages 27-32Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2017.08.009
Keywords
Odontonema cuspidatum; Acanthaceae; Iridoid glycosides; Antimalarial activity and antimicrobial activity
Categories
Funding
- National Center for Natural Products Research, The University of Mississippi, School of Pharmacy, Mississippi, USA
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Two new iridoid glycosides, named 6 beta-O-methyl-unedoside (1) and 6 beta-O-methyl-5-deoxythunbergioside (2) along with two known phenyl propanoid glucoside compounds dolichandroside A (3) and verbascoside (4) were isolated from the aerial parts of Odontonema cuspidatum (Nees) Kuntze (Acanthaceae). Structure elucidation of the new compounds was established by interpretation of their 1D and 2D-NMR spectral data by comparing with literatures, HRESIMS and optical activity measurement. The isolated compounds were tested for their in vitro antimicrobial and antimalarial activities. Compound 4 showed a moderate antimicrobial activity against E. coli with IC50 value of 17.5 mu M in comparing with Vancomycin and Cefotaxime.
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