Journal
PHYTOCHEMISTRY LETTERS
Volume 20, Issue -, Pages 196-199Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2017.04.023
Keywords
Endophytic fungus; Talaromyces stipitatus; Depsidones; Antibacterial activity; alpha-Glucosidase inhibitory activity
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Funding
- National Natural Science Foundation of China [21472251, 41376149, 41404134]
- Science and Technology Plan Project of Guangdong Province of China [2013B021100011]
- Key Project of Natural Science Foundation of Guangdong Province [2016A040403091]
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An endophytic fungus (Talaromyces stipitatus SK-4) was isolated from the leaves of a mangrove plant Acanthus ilicifolius. Its crude extract exhibited significant antibacterial activity and was purified to afford two new depsidones, talaromyones A and B (1 and 2), along with five known depsidone analogs (3-7). Their structures, including absolute configuration, were elucidated through extensive spectroscopic data analysis and modified Mosher's method. Compound 2 showed antibacterial activity against Bacillus subtilis with an MIC value of 12.5 mu g/mL. In the inhibitory assay against alpha-glucosidase, compounds 2, 4 and 5 displayed moderate activities with IC50 values ranging from 48.4 to 99.8 mu M.
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