Journal
PHYTOCHEMISTRY
Volume 138, Issue -, Pages 128-133Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2017.02.023
Keywords
Cibotium barometz (L) J. Sm.; Dicksoniaceae; Hemiterpene glycosides; Hepatoprotection
Categories
Funding
- CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-3-011]
Ask authors/readers for more resources
Five previously undescribed hemiterpene glycosides, cibotiumbarosides E-I, and two known hemiterpene glucosides, were isolated from the rhizome of Cibotium barometz (L.) J. Sm. The structures of cibotiumbarosides E-I were established by 1D and 2D NMR spectroscopic analyses and HRMS. The absolute configuration of the aglycone of cibotiumbaroside E was assigned by calculated ECD with the TDDFT method. Cibotiumbarosides F and I both exhibited remarkable hepatoprotective activity against APAP-induced acute liver damage in vitro, which were more effective than the positive control, bicyclol. On the other hand, seven hemiterpene glycosides were all inactive in assays of cytotoxicity, neuro-protection, antidiabetes and anti-inflammation. (C) 2017 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available