Journal
PHYTOCHEMISTRY
Volume 137, Issue -, Pages 87-93Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2017.01.019
Keywords
Juglans mandshurica Maxim; Juglandaceae; Neolignans; Anti-obesity; Lipolysis; O-2 consumption
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Funding
- National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology, Republic of Korea [NRF-2016R1A2B4006742]
- National Research Foundation of Korea - Ministry of Education, Science and Technology, Republic of Korea [NRF-2014R1A6A3A04056472]
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Juglans mandshurica Maxim. (Juglandaceae) is a traditional folk medicine used for treatment of dermatosis and to relieve aches in Korea and China. In this study, eight compounds, along with six known compounds, were isolated from the fruit of J. mandshurica. Among the six known compounds, the absolute configuration of two compounds were determined. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 10 and 2D NMR and CD spectroscopic data. All isolated compounds were tested for their lipolytic activities in differentiated adipocytes using C3H10T1/2 mouse embryonic fibroblasts. Among them, 2-(4-formyl-2-methoxyphenoxy)-propan-1,3-diol and 2-14-(3-hydroxypropy1)-2-methoxyphenoxyl-1,3-propanediol exhibited the most potent lipolytic activities. (C) 2017 Elsevier Ltd. All rights reserved.
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