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CIRCULATION-CARDIOVASCULAR GENETICS (2015)
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SCIENCE SIGNALING (2015)
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CELL AND TISSUE RESEARCH (2015)
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HAEMATOLOGICA (2015)
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HUMAN MOLECULAR GENETICS (2015)
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JOURNAL OF EXPERIMENTAL MEDICINE (2015)
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PLOS ONE (2015)
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PLOS ONE (2015)
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CANCER DISCOVERY (2015)
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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)
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AMERICAN JOURNAL OF PATHOLOGY (2014)
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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)
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BIOCHEMICAL SOCIETY TRANSACTIONS (2014)
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)
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BLOOD (2014)
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BRAIN RESEARCH (2014)
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BREAST CANCER RESEARCH AND TREATMENT (2014)
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CANCER RESEARCH (2014)
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CANCER RESEARCH (2014)
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CELL (2014)
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DEVELOPMENTAL DYNAMICS (2014)
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EMBO REPORTS (2014)
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EUROPEAN HEART JOURNAL (2014)
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EUROPEAN HEART JOURNAL (2014)
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EUROPEAN JOURNAL OF HUMAN GENETICS (2014)
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Sara Ortica et al.
FASEB JOURNAL (2014)
ADAM10 Regulates Notch Function in Intestinal Stem Cells of Mice
Yu-Hwai Tsai et al.
GASTROENTEROLOGY (2014)
Signaling Involved in Hair Follicle Morphogenesis and Development
Pisal Rishikaysh et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)
Basal body proteins regulate Notch signaling through endosomal trafficking
Carmen C. Leitch et al.
JOURNAL OF CELL SCIENCE (2014)
The deubiquitinase U5P28 controls intestinal homeostasis and promotes colorectal cancer
Markus E. Diefenbacher et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses
Nicolas Fasnacht et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2014)
Notch signaling and new therapeutic options in liver disease
Carola Maria Morell et al.
JOURNAL OF HEPATOLOGY (2014)
Macrophage heterogeneity in liver injury and fibrosis
Frank Tacke et al.
JOURNAL OF HEPATOLOGY (2014)
NOTCH1 Mutations Occur Early during Cutaneous Squamous Cell Carcinogenesis
Andrew P. South et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)
Identification of genomic alterations in oesophageal squamous cell cancer
Yongmei Song et al.
NATURE (2014)
Endothelial Notch activity promotes angiogenesis and osteogenesis in bone
Saravana K. Ramasamy et al.
NATURE (2014)
The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis
Katie Bentley et al.
NATURE CELL BIOLOGY (2014)
Genetic landscape of esophageal squamous cell carcinoma
Yi-Bo Gao et al.
NATURE GENETICS (2014)
A new tumor suppressor role for the Notch pathway in bladder cancer
Theodoros Rampias et al.
NATURE MEDICINE (2014)
A NOTCH 1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia
Daniel Herranz et al.
NATURE MEDICINE (2014)
Therapeutic modulation of Notch signalling - are we there yet?
Emma R. Andersson et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Signalling dynamics in vertebrate segmentation
Alexis Hubaud et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
GLIAL CELLS AS PROGENITORS AND STEM CELLS: NEW ROLES IN THE HEALTHY AND DISEASED BRAIN
Leda Dimou et al.
PHYSIOLOGICAL REVIEWS (2014)
NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers
Hongfang Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia
Yumi Yashiro-Ohtani et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Notch regulation of myogenic versus endothelial fates of cells that migrate from the somite to the limb
Alicia Mayeuf-Louchart et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
The cellular and molecular origin of tumor-associated macrophages
Ruth A. Franklin et al.
SCIENCE (2014)
The Tumor Suppressor Ikaros Shapes the Repertoire of Notch Target Genes in T Cells
Anne-Solen Geimer Le Lay et al.
SCIENCE SIGNALING (2014)
Systematic identification of signaling pathways with potential to confer anticancer drug resistance
Colin A. Martz et al.
SCIENCE SIGNALING (2014)
Structure and Function of the CSL-KyoT2 Corepressor Complex: A Negative Regulator of Notch Signaling
Kelly J. Collins et al.
STRUCTURE (2014)
Regulation of Vascular Smooth Muscle Cell Phenotype in Three-Dimensional Coculture System by Jagged1-Selective Notch3 Signaling
Aparna Bhattacharyya et al.
TISSUE ENGINEERING PART A (2014)
Notch signal integration in the vasculature during remodeling
Bahman Rostama et al.
VASCULAR PHARMACOLOGY (2014)
Evidence against a Stem Cell Origin of New Hepatocytes in a Common Mouse Model of Chronic Liver Injury
Johanna R. Schaub et al.
CELL REPORTS (2014)
Nontranscriptional Role of Hif-1α in Activation of γ-Secretase and Notch Signaling in Breast Cancer
Jennifer C. Villa et al.
CELL REPORTS (2014)
Non-canonical Notch signaling represents an ancestral mechanism to regulate neural differentiation
Michael J. Layden et al.
EVODEVO (2014)
RBPJ, the Major Transcriptional Effector of Notch Signaling, Remains Associated with Chromatin throughout Mitosis, Suggesting a Role in Mitotic Bookmarking
Robert J. Lake et al.
PLOS GENETICS (2014)
Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states
Lauren LeBon et al.
ELIFE (2014)
Non-canonical Notch signaling drives activation and differentiation of peripheral CD4+ T cells
Anushka Dongre et al.
FRONTIERS IN IMMUNOLOGY (2014)
Sequestration of latent TGF-beta binding protein 1 into CADASIL-related Notch3-ECD deposits
Jessica Kast et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2014)
Non-canonical Notch signaling in cancer and immunity
Furkan Ayaz et al.
FRONTIERS IN ONCOLOGY (2014)
A Recurrent PDGFRB Mutation Causes Familial Infantile Myofibromatosis
Yee Him Cheung et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2013)
Mutations in PDGFRB Cause Autosomal-Dominant Infantile Myofibromatosis
John A. Martignetti et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2013)
Mutation of HES7 in a Large Extended Family With Spondylocostal Dysostosis and Dextrocardia With Situs Inversus
Duncan B. Sparrow et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2013)
CCR2 Deficiency, Dysregulation of Notch Signaling, and Spontaneous Pulmonary Arterial Hypertension
Yen-Rei A. Yu et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)
Notch in the Intestine: Regulation of Homeostasis and Pathogenesis
Taeko K. Noah et al.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 75 (2013)
Soluble Jagged1 Inhibits Pulmonary Hypertension by Attenuating Notch Signaling
Yongguang Xiao et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)
γ-Secretase inhibitors and modulators
Todd E. Golde et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2013)
Endothelial RAF1/ERK activation regulates arterial morphogenesis
Yong Deng et al.
BLOOD (2013)
Notch controls generation and function of human effector CD8+ T cells
Loes M. Kuijk et al.
BLOOD (2013)
Spatiotemporal disorder in the axial skeleton development of the Mesp2-null mouse: A model of spondylocostal dysostosis and spondylothoracic dysostosis
Yuji Makino et al.
BONE (2013)
Abnormal recruitment of extracellular matrix proteins by excess Notch3ECD: a new pathomechanism in CADASIL
Marie Monet-Lepretre et al.
BRAIN (2013)
A phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503)
S. Sahebjam et al.
BRITISH JOURNAL OF CANCER (2013)
A Critical Role for Notch Signaling in the Formation of Cholangiocellular Carcinomas
Steffen Zender et al.
CANCER CELL (2013)
Loss of TGF-β Adaptor β2SP Activates Notch Signaling and SOX9 Expression in Esophageal Adenocarcinoma
Shumei Song et al.
CANCER RESEARCH (2013)
Role of PFKFB3-Driven Glycolysis in Vessel Sprouting
Katrien De Bock et al.
CELL (2013)
Numb Localizes at Endosomes and Controls the Endosomal Sorting of Notch after Asymmetric Division in Drosophila
Lydie Couturier et al.
CURRENT BIOLOGY (2013)
Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme
Ana Terriente-Felix et al.
DEVELOPMENT (2013)
Patterning and cell fate in the inner ear: a case for Notch in the chicken embryo
Joana Neves et al.
DEVELOPMENT GROWTH & DIFFERENTIATION (2013)
Metameric pattern of intervertebral disc/vertebral body is generated independently of Mesp2/Ripply-mediated rostro-caudal patterning of somites in the mouse embryo
Yu Takahashi et al.
DEVELOPMENTAL BIOLOGY (2013)
ETS Factors Regulate Vegf-Dependent Arterial Specification
Joshua D. Wythe et al.
DEVELOPMENTAL CELL (2013)
The Extracellular Domain of Notch2 Increases Its Cell-Surface Abundance and Ligand Responsiveness during Kidney Development
Zhenyi Liu et al.
DEVELOPMENTAL CELL (2013)
Endothelio-Mesenchymal Interaction Controls runx1 Expression and Modulates the notch Pathway to Initiate Aortic Hematopoiesis
Charlotte Richard et al.
DEVELOPMENTAL CELL (2013)
Jagged1 is the major regulator of notch-dependent cell fate in proximal airways
Shubing Zhang et al.
DEVELOPMENTAL DYNAMICS (2013)
Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma
Darjus Felix Tschaharganeh et al.
GASTROENTEROLOGY (2013)
Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway
Kyu-Sun Lee et al.
GENES & DEVELOPMENT (2013)
Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signaling
Mitsuteru Kitade et al.
GENES & DEVELOPMENT (2013)
Dynamic binding of RBPJ is determined by Notch signaling status
David Castel et al.
GENES & DEVELOPMENT (2013)
Robust cellular reprogramming occurs spontaneously during liver regeneration
Kilangsungla Yanger et al.
GENES & DEVELOPMENT (2013)
Novel MIR143-NOTCH Fusions in Benign and Malignant Glomus Tumors
Juan-Miguel Mosquera et al.
GENES CHROMOSOMES & CANCER (2013)
Constitutive Notch2 signaling induces hepatic tumors in mice
Michael T. Dill et al.
HEPATOLOGY (2013)
Canonical Notch2 signaling determines biliary cell fates of embryonic hepatoblasts and adult hepatocytes independent of Hes1
Petia Jeliazkova et al.
HEPATOLOGY (2013)
Autosomal dominant spondylocostal dysostosis is caused by mutation in TBX6
Duncan B. Sparrow et al.
HUMAN MOLECULAR GENETICS (2013)
miR-30a Regulates Endothelial Tip Cell Formation and Arteriolar Branching
Qiu Jiang et al.
HYPERTENSION (2013)
Lateral inhibition and neurogenesis: novel aspects in motion
Pau Formosa-Jordan et al.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2013)
Notch gain of function inhibits chondrocyte differentiation via Rbpj-dependent suppression of Sox9
Shan Chen et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2013)
α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals
Loredana Puca et al.
JOURNAL OF CELL SCIENCE (2013)
Blockade of individual Notch ligands and receptors controls graft-versus-host disease
Ivy T. Tran et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Whole exome sequencing of adenoid cystic carcinoma
Philip J. Stephens et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice
Romina Fiorotto et al.
JOURNAL OF HEPATOLOGY (2013)
Notch Signaling Regulates Follicular Helper T Cell Differentiation
Floriane Auderset et al.
JOURNAL OF IMMUNOLOGY (2013)
Notch-Regulated Periphery B Cell Differentiation Involves Suppression of E Protein Function
Ping Zhang et al.
JOURNAL OF IMMUNOLOGY (2013)
Ectopic Expression of Activated Notch or SOX2 Reveals Similar and Unique Roles in the Development of the Sensory Cell Progenitors in the Mammalian Inner Ear
Wei Pan et al.
JOURNAL OF NEUROSCIENCE (2013)
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
Meritxell Huch et al.
NATURE (2013)
The mutational landscape of adenoid cystic carcinoma
Allen S. Ho et al.
NATURE GENETICS (2013)
Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy
Guillermo Luxan et al.
NATURE MEDICINE (2013)
Hes1 and Hes5 regulate vascular remodeling and arterial specification of endothelial cells in brain vascular development
Masashi Kitagawa et al.
MECHANISMS OF DEVELOPMENT (2013)
Notch Inhibition Induces Cochlear Hair Cell Regeneration and Recovery of Hearing after Acoustic Trauma
Kunio Mizutari et al.
NEURON (2013)
Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKb
S. Jin et al.
ONCOGENE (2013)
被撤回的出版物: The Different Role of Notch1 and Notch2 in Astrocytic Gliomas (Retracted article. See vol. 14, 2019)
Peng Xu et al.
PLOS ONE (2013)
The Significance of Notch1 Compared with Notch3 in High Metastasis and Poor Overall Survival in Hepatocellular Carcinoma
Liang Zhou et al.
PLOS ONE (2013)
Notch Signaling Maintains Neural Rosette Polarity
Heather Main et al.
PLOS ONE (2013)
Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry
Michael J. Kluk et al.
PLOS ONE (2013)
Activation of Notch Signaling Is Required for Cholangiocarcinoma Progression and Is Enhanced by Inactivation of p53 In Vivo (Publication with Expression of Concern. See vol. 14, 2019)
Mona El Khatib et al.
PLOS ONE (2013)
Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development
Natalia Sacilotto et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Landscape of somatic mutations and clonal evolution in mantle cell lymphoma
Silvia Bea et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Brief Report: Blockade of Notch Signaling in Muscle Stem Cells Causes Muscular Dystrophic Phenotype and Impaired Muscle Regeneration
Shuibin Lin et al.
STEM CELLS (2013)
A Critical Role for Sox9 in Notch-Induced Astrogliogenesis and Stem Cell Maintenance
Simone Martini et al.
STEM CELLS (2013)
Hypoxia-Induced Arterial Differentiation Requires Adrenomedullin and Notch Signaling
Fredrik Lanner et al.
STEM CELLS AND DEVELOPMENT (2013)
Accelerating the Tempo of the Segmentation Clock by Reducing the Number of Introns in the Hes7 Gene
Yukiko Harima et al.
CELL REPORTS (2013)
Regulation of innate and adaptive immunity by Notch
Freddy Radtke et al.
NATURE REVIEWS IMMUNOLOGY (2013)
RBPJ Mutations Identified in Two Families Affected by Adams-Oliver Syndrome
Susan J. Hassed et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2012)
Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane
Lea Scheppke et al.
BLOOD (2012)
Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma
Robert Kridel et al.
BLOOD (2012)
miR-27b controls venous specification and tip cell fate
Dauren Biyashev et al.
BLOOD (2012)
The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis
Gemma Bridge et al.
BLOOD (2012)
BMP9 and BMP10 are critical for postnatal retinal vascular remodeling
Nicolas Ricard et al.
BLOOD (2012)
Endothelial cell metabolism and implications for cancer therapy
U. Harjes et al.
BRITISH JOURNAL OF CANCER (2012)
Elevated Epidermal Thymic Stromal Lymphopoietin Levels Establish an Antitumor Environment in the Skin
Shadmehr Demehri et al.
CANCER CELL (2012)
Notch signalling in smooth muscle cells during development and disease
Charles Fouillade et al.
CARDIOVASCULAR RESEARCH (2012)
A Mechanism for Gene-Environment Interaction in the Etiology of Congenital Scoliosis
Duncan B. Sparrow et al.
CELL (2012)
Multifocal Epithelial Tumors and Field Cancerization from Loss of Mesenchymal CSL Signaling
Bing Hu et al.
CELL (2012)
Current perspectives of the signaling pathways directing neural crest induction
Timothy J. Stuhlmiller et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2012)
Notch Activation of Jagged1 Contributes to the Assembly of the Arterial Wall
Lauren J. Manderfield et al.
CIRCULATION (2012)
Identification of de novo mutations and rare variants in hypoplastic left heart syndrome
M. Iascone et al.
CLINICAL GENETICS (2012)
Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism
Jonas Ahnfelt-Ronne et al.
DEVELOPMENT (2012)
Delta-like 1 and lateral inhibition during hair cell formation in the chicken inner ear: evidence against cis-inhibition
Elena Chrysostomou et al.
DEVELOPMENT (2012)
Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells
Mitsuru Morimoto et al.
DEVELOPMENT (2012)
The role of Hes genes in intestinal development, homeostasis and tumor formation
Taro Ueo et al.
DEVELOPMENT (2012)
A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation
Hung Ping Shih et al.
DEVELOPMENT (2012)
Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas
Daniel Kopinke et al.
DEVELOPMENTAL BIOLOGY (2012)
Optical Tweezers Studies on Notch: Single-Molecule Interaction Strength Is Independent of Ligand Endocytosis
Bhupinder Shergill et al.
DEVELOPMENTAL CELL (2012)
Botch Promotes Neurogenesis by Antagonizing Notch
Zhikai Chi et al.
DEVELOPMENTAL CELL (2012)
Stalk Cell Phenotype Depends on Integration of Notch and Smad1/5 Signaling Cascades
Ivan M. Moya et al.
DEVELOPMENTAL CELL (2012)
Single-Cell-Resolution Imaging of the Impact of Notch Signaling and Mitosis on Segmentation Clock Dynamics
Emilie A. Delaune et al.
DEVELOPMENTAL CELL (2012)
Notch Ligand Endocytosis Generates Mechanical Pulling Force Dependent on Dynamin, Epsins, and Actin
Laurence Meloty-Kapella et al.
DEVELOPMENTAL CELL (2012)
Alagille syndrome: pathogenesis, diagnosis and management
Peter D. Turnpenny et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2012)
Notch Signaling Is Activated in Human Hepatocellular Carcinoma and Induces Tumor Formation in Mice
Augusto Villanueva et al.
GASTROENTEROLOGY (2012)
Liver Progenitor Cells Yield Functional Hepatocytes in Response to Chronic Liver Injury in Mice
Regina Espanol-Suner et al.
GASTROENTEROLOGY (2012)
Notch Activation by the Metalloproteinase ADAM17 Regulates Myeloproliferation and Atopic Barrier Immunity by Suppressing Epithelial Cytokine Synthesis
Aditya Murthy et al.
IMMUNITY (2012)
The Ubiquitin-specific Protease 12 (USP12) Is a Negative Regulator of Notch Signaling Acting on Notch Receptor Trafficking toward Degradation
Julien Moretti et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Cholangiocarcinomas can originate from hepatocytes in mice
Biao Fan et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes
Sayaka Sekiya et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells
Marie Cherrier et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Whole-genome sequencing identifies recurrent somatic NOTCH2 mutations in splenic marginal zone lymphoma
Mark J. Kiel et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Programming of Regulatory T Cells from Pluripotent Stem Cells and Prevention of Autoimmunity
Rizwanul Haque et al.
JOURNAL OF IMMUNOLOGY (2012)
Epithelial Cell-Intrinsic Notch Signaling Plays an Essential Role in the Maintenance of Gut Immune Homeostasis
Yuuki Obata et al.
JOURNAL OF IMMUNOLOGY (2012)
Alzheimer's Disease: Presenilin 2-Sparing γ-Secretase Inhibition Is a Tolerable Aβ Peptide-Lowering Strategy
Tomas Borgegard et al.
JOURNAL OF NEUROSCIENCE (2012)
Neurogenic Subventricular Zone Stem/Progenitor Cells Are Notch1-Dependent in Their Active But Not Quiescent State
Onur Basak et al.
JOURNAL OF NEUROSCIENCE (2012)
miR-210 activates notch signaling pathway in angiogenesis induced by cerebral ischemia
Yuan-Lei Lou et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2012)
Fbw7 and p53 Cooperatively Suppress Advanced and Chromosomally Unstable Intestinal Cancer
Jonathan E. Grim et al.
MOLECULAR AND CELLULAR BIOLOGY (2012)
NOTCH1 Nuclear Interactome Reveals Key Regulators of Its Transcriptional Activity and Oncogenic Function
Ahmad Yatim et al.
MOLECULAR CELL (2012)
The mutational landscape of lethal castration-resistant prostate cancer
Catherine S. Grasso et al.
NATURE (2012)
Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease
Luke Boulter et al.
NATURE MEDICINE (2012)
Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
Panagiotis Ntziachristos et al.
NATURE MEDICINE (2012)
BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets
Luca Tiberi et al.
NATURE NEUROSCIENCE (2012)
Pericytes as a new target for pathological processes in CADASIL
Dorota Dziewulska et al.
NEUROPATHOLOGY (2012)
Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin
I. Hayashi et al.
ONCOGENE (2012)
Acetylation controls Notch3 stability and function in T-cell leukemia
R. Palermo et al.
ONCOGENE (2012)
Overactivation of Notch1 Signaling Induces Ectopic Hair Cells in the Mouse Inner Ear in an Age-Dependent Manner
Zhiyong Liu et al.
PLOS ONE (2012)
Notch2 and Notch3 Function Together to Regulate Vascular Smooth Muscle Development
Qingqing Wang et al.
PLOS ONE (2012)
Loss of RBPj in Postnatal Excitatory Neurons Does Not Cause Neurodegeneration or Memory Impairments in Aged Mice
Chihiro Sato et al.
PLOS ONE (2012)
Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
Jens G. Lohr et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Differentiation of vascular smooth muscle cells from local precursors during embryonic and adult arteriogenesis requires Notch signaling
Linda Chang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
A Critical Requirement for Notch Signaling in Maintenance of the Quiescent Skeletal Muscle Stem Cell State
Philippos Mourikis et al.
STEM CELLS (2012)
Notch Signaling Is Necessary to Maintain Quiescence in Adult Muscle Stem Cells
Christopher R. R. Bjornson et al.
STEM CELLS (2012)
Lfng regulates the synchronized oscillation of the mouse segmentation clock via trans-repression of Notch signalling
Yusuke Okubo et al.
NATURE COMMUNICATIONS (2012)
Comparative Genomic Analysis of Esophageal Adenocarcinoma and Squamous Cell Carcinoma
Nishant Agrawal et al.
CANCER DISCOVERY (2012)
The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways
Olivier Boucherat et al.
BIOLOGY OPEN (2012)
Notch Induces Myofibroblast Differentiation of Alveolar Epithelial Cells via Transforming Growth Factor-β-Smad3 Pathway
Kana Aoyagi-Ikeda et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2011)
Soluble Jagged-1 Inhibits Neointima Formation by Attenuating Notch-Herp2 Signaling
Vincenza Caolo et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2011)
Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease
Yi Zhang et al.
BLOOD (2011)
Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor
Wei Zheng et al.
BLOOD (2011)
The Notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development
Kyle Niessen et al.
BLOOD (2011)
Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells
Nilay Sethi et al.
CANCER CELL (2011)
DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo
Ji-Liang Li et al.
CANCER RESEARCH (2011)
Notch-Dependent Differentiation of Adult Airway Basal Stem Cells
Jason R. Rock et al.
CELL STEM CELL (2011)
Signaling During Epicardium and Coronary Vessel Development
Jose Maria Perez-Pomares et al.
CIRCULATION RESEARCH (2011)
Notch Signaling Regulates Smooth Muscle Differentiation of Epicardium-Derived Cells
Thomas Grieskamp et al.
CIRCULATION RESEARCH (2011)
Differential Notch Signaling in the Epicardium Is Required for Cardiac Inflow Development and Coronary Vessel Morphogenesis
Gonzalo del Monte et al.
CIRCULATION RESEARCH (2011)
Rbpj regulates development of prosensory cells in the mammalian inner ear
Norio Yamamoto et al.
DEVELOPMENTAL BIOLOGY (2011)
Noncanonical Notch Function in Motor Axon Guidance Is Mediated by Rac GTPase and the GEF1 Domain of Trio
Jeong K. Song et al.
DEVELOPMENTAL DYNAMICS (2011)
Dicer is Required for the Maintenance of Notch Signaling and Gliogenic Competence During Mouse Retinal Development
Sean A. Georgi et al.
DEVELOPMENTAL NEUROBIOLOGY (2011)
The Notch signaling pathway: Molecular basis of cell context dependency
Ralf Schwanbeck et al.
EUROPEAN JOURNAL OF CELL BIOLOGY (2011)
Dll1- and Dll4-Mediated Notch Signaling Are Required for Homeostasis of Intestinal Stem Cells
Luca Pellegrinet et al.
GASTROENTEROLOGY (2011)
Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium
Toshiro Sato et al.
GASTROENTEROLOGY (2011)
Roles of Drosophila Deltex in Notch receptor endocytic trafficking and activation
Kenta Yamada et al.
GENES TO CELLS (2011)
Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis
Andreia V. Pinho et al.
GUT (2011)
Ductular Reactions in Human Liver: Diversity at the Interface
Annette S. H. Gouw et al.
HEPATOLOGY (2011)
Notch inhibition by the ligand Delta-Like 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis
Gavin Chapman et al.
HUMAN MOLECULAR GENETICS (2011)
Mutations in NOTCH2 in Families with Hajdu-Cheney Syndrome
Jacek Majewski et al.
HUMAN MUTATION (2011)
Notch2 Receptor Signaling Controls Functional Differentiation of Dendritic Cells in the Spleen and Intestine
Kanako L. Lewis et al.
IMMUNITY (2011)
Genetic Evidence That Intestinal Notch Functions Vary Regionally and Operate through a Common Mechanism of Math1 Repression
Tae-Hee Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
The miR-143/145 Cluster Is a Novel Transcriptional Target of Jagged-1/Notch Signaling in Vascular Smooth Muscle Cells
Joshua M. Boucher et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice
Zhenyi Liu et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration
Yann Malato et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans
Elly Sau-Wai Ngan et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation
Roya Babaei-Jadidi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway
Patrick Viatour et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Blockade of Notch Ligand Delta1 Promotes Allograft Survival by Inhibiting Alloreactive Th1 Cells and Cytotoxic T Cell Generation
Leonardo V. Riella et al.
JOURNAL OF IMMUNOLOGY (2011)
Notch Ligand Delta-Like 4 Blockade Alleviates Experimental Autoimmune Encephalomyelitis by Promoting Regulatory T Cell Development
Ribal Bassil et al.
JOURNAL OF IMMUNOLOGY (2011)
Canonical Notch Signaling Is Not Necessary for Prosensory Induction in the Mouse Cochlea: Insights from a Conditional Mutant of RBPjκ
Martn L. Basch et al.
JOURNAL OF NEUROSCIENCE (2011)
Notch1 Is an Independent Prognostic Factor for Patients With Glioma
Jiang Li et al.
JOURNAL OF SURGICAL ONCOLOGY (2011)
The mouse notches up another success: understanding the causes of human vertebral malformation
Duncan B. Sparrow et al.
MAMMALIAN GENOME (2011)
A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia
Apostolos Klinakis et al.
NATURE (2011)
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente et al.
NATURE (2011)
Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase
Virginia Guarani et al.
NATURE (2011)
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
Kenichiro Furuyama et al.
NATURE GENETICS (2011)
Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis
Bertrand Isidor et al.
NATURE GENETICS (2011)
Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss
Michael A. Simpson et al.
NATURE GENETICS (2011)
Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer
Dan R. Robinson et al.
NATURE MEDICINE (2011)
Activity-Induced Notch Signaling in Neurons Requires Arc/Arg3.1 and Is Essential for Synaptic Plasticity in Hippocampal Networks
Lavinia Alberi et al.
NEURON (2011)
Dual Roles of Notch in Regulation of Apically Restricted Mitosis and Apicobasal Polarity of Neuroepithelial Cells
Shinya Ohata et al.
NEURON (2011)
Delta1 Expression, Cell Cycle Exit, and Commitment to a Specific Secretory Fate Coincide within a Few Hours in the Mouse Intestinal Stem Cell System
Despina Stamataki et al.
PLOS ONE (2011)
Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase
Hideyuki Takeuchi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms
Sebastian K. -J. Landor et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma
Nicholas J. Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1
Nishant Agrawal et al.
SCIENCE (2011)
The Mutational Landscape of Head and Neck Squamous Cell Carcinoma
Nicolas Stransky et al.
SCIENCE (2011)
The Epigenetic Regulation of Stem Cell Factors in Hepatic Stellate Cells
Sven Reister et al.
STEM CELLS AND DEVELOPMENT (2011)
Notch Activation Enhances the Microglia-Mediated Inflammatory Response Associated With Focal Cerebral Ischemia
Zelan Wei et al.
STROKE (2011)
Proliferating Reactive Astrocytes Are Regulated by Notch-1 in the Peri-Infarct Area After Stroke
Issei S. Shimada et al.
STROKE (2011)
Association of JAG1 with Bone Mineral Density and Osteoporotic Fractures: A Genome-wide Association Study and Follow-up Replication Studies
Annie W. C. Kung et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2010)
New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes
Helen Sheldon et al.
BLOOD (2010)
Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion
J. Chen et al.
BRITISH JOURNAL OF CANCER (2010)
Targeting Specific Regions of the Notch3 Ligand-Binding Domain Induces Apoptosis and Inhibits Tumor Growth in Lung Cancer
Luping Lin et al.
CANCER RESEARCH (2010)
Quiescent and Active Hippocampal Neural Stem Cells with Distinct Morphologies Respond Selectively to Physiological and Pathological Stimuli and Aging
Sebastian Lugert et al.
CELL STEM CELL (2010)
Notch1 signaling is mediated by importins alpha 3, 4, and 7
Kerstin Huenniger et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2010)
Inhibition of Notch1-Dependent Cardiomyogenesis Leads to a Dilated Myopathy in the Neonatal Heart
Konrad Urbanek et al.
CIRCULATION RESEARCH (2010)
Notch3 Is Critical for Proper Angiogenesis and Mural Cell Investment
Hua Liu et al.
CIRCULATION RESEARCH (2010)
Endocytic Internalization Routes Required for Delta/Notch Signaling
Sarah L. Windler et al.
CURRENT BIOLOGY (2010)
Patent ductus arteriosus in mice with smooth muscle-specific Jag1 deletion
Xuesong Feng et al.
DEVELOPMENT (2010)
Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome
Jennifer J. Hofmann et al.
DEVELOPMENT (2010)
Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression
Ulrika Marklund et al.
DEVELOPMENT (2010)
The Wnt/β-Catenin Pathway Modulates Vascular Remodeling and Specification by Upregulating DII4/Notch Signaling
Monica Corada et al.
DEVELOPMENTAL CELL (2010)
Dynamic Filopodia Transmit Intermittent Delta-Notch Signaling to Drive Pattern Refinement during Lateral Inhibition
Michael Cohen et al.
DEVELOPMENTAL CELL (2010)
Interactions between Notch- and hypoxia-induced transcriptomes in embryonic stem cells
Heather Main et al.
EXPERIMENTAL CELL RESEARCH (2010)
Regulation of skeletal myogenesis by Notch
Matthew F. Buas et al.
EXPERIMENTAL CELL RESEARCH (2010)
Atonal Homolog 1 Is Required for Growth and Differentiation Effects of Notch/γ-Secretase Inhibitors on Normal and Cancerous Intestinal Epithelial Cells
Avedis Kazanjian et al.
GASTROENTEROLOGY (2010)
F-box and WD Repeat Domain-Containing 7 Regulates Intestinal Cell Lineage Commitment and Is a Haploinsufficient Tumor Suppressor
Rocio Sancho et al.
GASTROENTEROLOGY (2010)
Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex
Robert Liefke et al.
GENES & DEVELOPMENT (2010)
Notch Signaling Regulates Formation of the Three-Dimensional Architecture of Intrahepatic Bile Ducts in Mice
Erin E. Sparks et al.
HEPATOLOGY (2010)
Hes1 Is a Critical but Context-Dependent Mediator of Canonical Notch Signaling in Lymphocyte Development and Transformation
Agnieszka A. Wendorff et al.
IMMUNITY (2010)
The Notch Effector Hey1 Associates with Myogenic Target Genes to Repress Myogenesis
Matthew F. Buas et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Convergence of Notch and β-catenin signaling induces arterial fate in vascular progenitors
Kohei Yamamizu et al.
JOURNAL OF CELL BIOLOGY (2010)
Control of Notch-ligand endocytosis by ligand-receptor interaction
Emil M. Hansson et al.
JOURNAL OF CELL SCIENCE (2010)
Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation
Luis Luna-Zurita et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease
Anne Joutel et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Notch2 Signaling Is Required for Potent Antitumor Immunity In Vivo
Koji Sugimoto et al.
JOURNAL OF IMMUNOLOGY (2010)
NFIA Controls Telencephalic Progenitor Cell Differentiation through Repression of the Notch Effector Hes1
Michael Piper et al.
JOURNAL OF NEUROSCIENCE (2010)
RBPJκ-Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus
Oliver Ehm et al.
JOURNAL OF NEUROSCIENCE (2010)
Notch Activity Levels Control the Balance between Quiescence and Recruitment of Adult Neural Stem Cells
Prisca Chapouton et al.
JOURNAL OF NEUROSCIENCE (2010)
Notch1 Is Required for Maintenance of the Reservoir of Adult Hippocampal Stem Cells
Jessica L. Ables et al.
JOURNAL OF NEUROSCIENCE (2010)
Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains
Itaru Imayoshi et al.
JOURNAL OF NEUROSCIENCE (2010)
Chronic DLL4 blockade induces vascular neoplasms
Minhong Yan et al.
NATURE (2010)
Therapeutic antibody targeting of individual Notch receptors
Yan Wu et al.
NATURE (2010)
Cis-interactions between Notch and Delta generate mutually exclusive signalling states
David Sprinzak et al.
NATURE (2010)
Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal
Adan Aguirre et al.
NATURE (2010)
Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex
Tohru Ishitani et al.
NATURE CELL BIOLOGY (2010)
Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes
Kelly L. Arnett et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors
Miguel Aste-Amezaga et al.
PLOS ONE (2010)
Atopic Dermatitis-Like Disease and Associated Lethal Myeloproliferative Disorder Arise from Loss of Notch Signaling in the Murine Skin
Alexis Dumortier et al.
PLOS ONE (2010)
Activated Notch1 Target Genes during Embryonic Cell Differentiation Depend on the Cellular Context and Include Lineage Determinants and Inhibitors
Franziska Meier-Stiegen et al.
PLOS ONE (2010)
Notch and MAML-1 Complexation Do Not Detectably Alter the DNA Binding Specificity of the Transcription Factor CSL
Cristina Del Bianco et al.
PLOS ONE (2010)
Notch signaling specifies prosensory domains via lateral induction in the developing mammalian inner ear
Byron H. Hartman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Thermodynamic and structural insights into CSL-DNA complexes
David R. Friedmann et al.
PROTEIN SCIENCE (2010)
Neonatal Stroke in Mice Causes Long-Term Changes in Neuronal Notch-2 Expression That May Contribute to Prolonged Injury
Lavinia Alberi et al.
STROKE (2010)
γ-Secretase-Dependent Cleavage Initiates Notch Signaling from the Plasma Membrane
Erika B. Sorensen et al.
TRAFFIC (2010)
Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors
Johan H. van Es et al.
NATURE COMMUNICATIONS (2010)
The Spectra of Clinical Phenotypes in Aplasia Cutis Congenita and Terminal Transverse Limb Defects
Katie M. G. Snape et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2009)
Notch1 Signaling in FIZZ1 Induction of Myofibroblast Differentiation
Tianju Liu et al.
AMERICAN JOURNAL OF PATHOLOGY (2009)
Down-regulation of the Notch Pathway in Human Airway Epithelium in Association with Smoking and Chronic Obstructive Pulmonary Disease
Ann E. Tilley et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009)
Beta-catenin modulates the level and transcriptional activity of Notch1/NICD through its direct interaction
Yun Hye Jin et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2009)
An early decrease in Notch activation is required for human TCR-αβ lineage differentiation at the expense of TCR-γδ T cells
Inge Van de Walle et al.
BLOOD (2009)
Notch signaling is required for proliferation but not for differentiation at a well-defined β-selection checkpoint during human T-cell development
Tom Taghon et al.
BLOOD (2009)
Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes
Eve Gazave et al.
BMC EVOLUTIONARY BIOLOGY (2009)
Congruence between NOTCH3 mutations and GOM in 131 CADASIL patients
Saara Tikka et al.
BRAIN (2009)
Heterozygosity for Hypoxia Inducible Factor 1α Decreases the Incidence of Thymic Lymphomas in a p53 Mutant Mouse Model
Jessica A. Bertout et al.
CANCER RESEARCH (2009)
A hierarchical cascade activated by non-canonical Notch signaling and the mTOR-Rictor complex regulates neglect-induced death in mammalian cells
L. R. Perumalsamy et al.
CELL DEATH AND DIFFERENTIATION (2009)
Smooth Muscle Notch1 Mediates Neointimal Formation After Vascular Injury
Yuxin Li et al.
CIRCULATION (2009)
NOTCH3 Expression Is Induced in Mural Cells Through an Autoregulatory Loop That Requires Endothelial-Expressed JAGGED1
Hua Liu et al.
CIRCULATION RESEARCH (2009)
Tumor-Initiating Cells of HER2-Positive Carcinoma Cell Lines Express the Highest Oncoprotein Levels and Are Sensitive to Trastuzumab
Alessandra Magnifico et al.
CLINICAL CANCER RESEARCH (2009)
Notch signaling controls liver development by regulating biliary differentiation
Yiwei Zong et al.
DEVELOPMENT (2009)
Notch signaling controls the balance of ciliated and secretory cell fates in developing airways
Po-Nien Tsao et al.
DEVELOPMENT (2009)
Notch signaling promotes airway mucous metaplasia and inhibits alveolar development
J. Sawalla Guseh et al.
DEVELOPMENT (2009)
Committed Neuronal Precursors Confer Astrocytic Potential on Residual Neural Precursor Cells
Masakazu Namihira et al.
DEVELOPMENTAL CELL (2009)
The Vacuolar Proton Pump, V-ATPase, Is Required for Notch Signaling and Endosomal Trafficking in Drosophila
Yan Yan et al.
DEVELOPMENTAL CELL (2009)
Cbf11 and Cbf12, the fission yeast CSL proteins, play opposing roles in cell adhesion and coordination of cell and nuclear division
Martin Prevorovsky et al.
EXPERIMENTAL CELL RESEARCH (2009)
Notch Signaling as Gatekeeper of Rat Acinar-to-β-Cell Conversion in Vitro
Luc Baeyens et al.
GASTROENTEROLOGY (2009)
Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window
Corentin Cras-Meneur et al.
GENES & DEVELOPMENT (2009)
MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury
Mei Xin et al.
GENES & DEVELOPMENT (2009)
Notch2 Signaling Promotes Biliary Epithelial Cell Fate Specification and Tubulogenesis During Bile Duct Development in Mice
Jan S. Tchorz et al.
HEPATOLOGY (2009)
Differences in hydroxylation and binding of Notch and HIF-1α demonstrate substrate selectivity for factor inhibiting HIF-1 (FIH-1)
Sarah E. Wilkins et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)
Numb Regulates Post-endocytic Trafficking and Degradation of Notch1
Melanie A. McGill et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
YB-1 Acts as a Ligand for Notch-3 Receptors and Modulates Receptor Activation
Thomas Rauen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Inhibition of Myogenesis by Notch: Evidence for Multiple Pathways
Matthew F. Buas et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2009)
Rbpj Cell Autonomous Regulation of Retinal Ganglion Cell and Cone Photoreceptor Fates in the Mouse Retina
Amy N. Riesenberg et al.
JOURNAL OF NEUROSCIENCE (2009)
Transcription factor RBP-J-mediated signaling represses the differentiation of neural stem cells into intermediate neural progenitors
Fang Gao et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2009)
Direct inhibition of the NOTCH transcription factor complex
Raymond E. Moellering et al.
NATURE (2009)
gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
Pedro J. Real et al.
NATURE MEDICINE (2009)
Notch3 signaling promotes the development of pulmonary arterial hypertension
Xiaodong Li et al.
NATURE MEDICINE (2009)
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke
Marie Carlen et al.
NATURE NEUROSCIENCE (2009)
Generating specificity and diversity in the transcriptional response to hypoxia
Urban Lendahl et al.
NATURE REVIEWS GENETICS (2009)
Epidermal homeostasis: a balancing act of stem cells in the skin
Cedric Blanpain et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis
A. Raafat et al.
ONCOGENE (2009)
Differential Expression of Notch Family Members in Astrocytomas and Medulloblastomas
Peng Xu et al.
PATHOLOGY & ONCOLOGY RESEARCH (2009)
Alterations of the Notch pathway in lung cancer
Britta Westhoff et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Direct Response to Notch Activation: Signaling Crosstalk and Incoherent Logic
Alena Krejci et al.
SCIENCE SIGNALING (2009)
The transcription factor RBP-J is essential for retinal cell differentiation and lamination
Min-Hua Zheng et al.
MOLECULAR BRAIN (2009)
Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndrome
Alberto S. Cornier et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2008)
A Notch1 ectodomain construct inhibits endothelial Notch signaling, tumor growth, and angiogenesis
Yasuhiro Funahashi et al.
CANCER RESEARCH (2008)
Cross-talk between Notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches
Paola Rizzo et al.
CANCER RESEARCH (2008)
Rumi is a CAP10 domain glycosyltransferase that modifies notch and is required for notch signaling
Melih Acar et al.
CELL (2008)
MicroRNA regulation of cell lineages in mouse and human embryonic stem cells
Kathryn N. Ivey et al.
CELL STEM CELL (2008)
Notch signaling regulates platelet-derived growth factor receptor-β expression in vascular smooth muscle cells
Shaobo Jin et al.
CIRCULATION RESEARCH (2008)
Developmental origin of smooth muscle cells in the descending aorta in mice
Per Wasteson et al.
DEVELOPMENT (2008)
Hairy2 functions through both DNA-binding and non DNA-binding mechanisms at the neural plate border in Xenopus
Massimo Nichane et al.
DEVELOPMENTAL BIOLOGY (2008)
Molecular separation of two signaling pathways for the receptor, Notch
Maude Le Gall et al.
DEVELOPMENTAL BIOLOGY (2008)
Multiple roles of notch signaling in the regulation of epidermal development
Mariko Moriyama et al.
DEVELOPMENTAL CELL (2008)
Drosophila HOPS and AP-3 Complex Genes Are Required for a Deltex-Regulated Activation of Notch in the Endosomal Trafficking Pathway
Marian Wilkin et al.
DEVELOPMENTAL CELL (2008)
Notch-regulated oligodendrocyte specification from radial glia in the spinal cord of zebrafish embryos
Ho Kim et al.
DEVELOPMENTAL DYNAMICS (2008)
Notch2 is required for the proliferation of cardiac neural crest-derived smooth muscle cells
Prajakta Varadkar et al.
DEVELOPMENTAL DYNAMICS (2008)
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2
Orbicia Riccio et al.
EMBO REPORTS (2008)
Notch signaling is required for exocrine regeneration after acute pancreatitis
Jens T. Sivere et al.
GASTROENTEROLOGY (2008)
A nonclassical bHLH-Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling
Kei Hori et al.
GENES & DEVELOPMENT (2008)
In vitro validation of γ-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia
Kim De Keersmaecker et al.
HAEMATOLOGICA (2008)
NOTCH2 mutations in marginal zone lymphoma
Gunhild Troen et al.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2008)
β-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development
Xinping Tan et al.
HEPATOLOGY (2008)
Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice
Fabian Geisler et al.
HEPATOLOGY (2008)
Interaction of master mind, big brain, neuralized and Notch genes of Droso-phila melanogaster as expressed in adult morphology
PETTER PORTIN et al.
HEREDITAS (2008)
Activating NOTCH3 mutation in a patient with small-vessel-disease of the brain
Charles Fouillade et al.
HUMAN MUTATION (2008)
O-Linked N-Acetylglucosamine Is Present on the Extracellular Domain of Notch Receptors
Aiko Matsuura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3
Kang Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
γ-Secretase Activation of Notch Signaling Regulates the Balance of Proximal and Distal Fates in Progenitor Cells of the Developing Lung
Po-Nien Tsao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
RAM-induced allostery facilitates assembly of a Notch pathway active transcription complex
David R. Friedmann et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Endosomal entry regulates Notch receptor activation in Drosophila melanogaster
Thomas Vaccari et al.
JOURNAL OF CELL BIOLOGY (2008)
Control of the adaptive response of the heart to stress via the Notch1 receptor pathway
Adrien Croquelois et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
Ikaros Regulates Notch Target Gene Expression in Developing Thymocytes
Sheila Chari et al.
JOURNAL OF IMMUNOLOGY (2008)
Role of the Notch ligand Delta1 in embryonic and adult mouse epidermis
Soline Estrach et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2008)
Notch1 Signaling in Pyramidal Neurons Regulates Synaptic Connectivity and Experience-Dependent Modifications of Acuity in the Visual Cortex
Martijn Dahlhaus et al.
JOURNAL OF NEUROSCIENCE (2008)
ETO, but not leukemogenic fusion protein AML1/ETO, augments RBP-Jκ/SHARP-mediated repression of Notch target genes
Daniela Salat et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
FBXW7 mutation in adult T-cell and B-cell acute lymphocytic leukemias
Jee Hoon Song et al.
LEUKEMIA RESEARCH (2008)
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
Tuomas Tammela et al.
NATURE (2008)
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans
Nicole King et al.
NATURE (2008)
Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition
Ryoichiro Kageyama et al.
NATURE NEUROSCIENCE (2008)
Mind bomb 1-expressing intermediate progenitors generate Notch signaling to maintain radial glial cells
Ki-Jun Yoon et al.
NEURON (2008)
Oscillations in notch signaling regulate maintenance of neural progenitors
Hiromi Shimojo et al.
NEURON (2008)
The many facets of Notch ligands
B. D'Souza et al.
ONCOGENE (2008)
Notch signalling synchronizes the zebrafish segmentation clock but is not needed to create somite boundaries
Ertugrul M. Ozbudak et al.
PLOS GENETICS (2008)
Notch Signaling Regulates Bile Duct Morphogenesis in Mice
Julie Lozier et al.
PLOS ONE (2008)
Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways
Xiaofeng Zheng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development
Frances A. High et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Notch signaling mediates hypoxia-induced tumor cell migration and invasion
Cecilia Sahlgren et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy
Yulia Nefedova et al.
BLOOD (2008)
Transforming growth factor-β(TGF-β1) down-regulates Notch3 in fibroblasts to promote smooth muscle gene expression
Simone Kennard et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1
Shinji Tagami et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Stabilization of beta-catenin affects mouse embryonic liver growth and hepatoblast fate
Thomas Decaens et al.
HEPATOLOGY (2008)
Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus
Joshua J. Breunig et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer
Wade T. Nottingham et al.
BLOOD (2007)
Notch1 expression and ligand interactions in progenitor cells of the mouse olfactory epithelium
Gerald A. Schwarting et al.
JOURNAL OF MOLECULAR HISTOLOGY (2007)
In vitro reconstitution of the modulation of Drosophila notch-ligand binding by fringe
Aiguo Xu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin
Kevin G. Leong et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
The transcriptional coactivator Mam11 is required for Notch2-mediated marginal zone B-cell development
Lizi Wu et al.
BLOOD (2007)
Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression
Carrie J. Shawber et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Liver regeneration
George K. Michalopoulos
JOURNAL OF CELLULAR PHYSIOLOGY (2007)
Presenilin: Running with scissors in the membrane
Dennis J. Selkoe et al.
CELL (2007)
Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex
Toshihiko Masui et al.
GENES & DEVELOPMENT (2007)
Notch signaling in vascular smooth muscle cells is required to pattern the cerebral vasculature
Aaron Proweller et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature
R. Sathish Srinivasan et al.
GENES & DEVELOPMENT (2007)
Synchrony dynamics during initiation, failure, and rescue of the segmentation clock
Ingmar H. Riedel-Kruse et al.
SCIENCE (2007)
Mastermind-like 1 is a specific coactivator of β-catenin transcription activation and is essential for colon carcinoma cell survival
Marie-Clotilde Alves-Guerra et al.
CANCER RESEARCH (2007)
Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma
Laura Gramantieri et al.
LIVER INTERNATIONAL (2007)
γ-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers
Jun Konishi et al.
CANCER RESEARCH (2007)
Asparaginyl hydroxylation of the notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor
Mathew L. Coleman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors
Jennifer O'Neil et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
miRNA expression analysis during normal zebrafish development and following inhibition of the hedgehog and notch signaling pathways
Elizabeth J. Thatcher et al.
DEVELOPMENTAL DYNAMICS (2007)
Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms
Stephen H. McKellar et al.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2007)
Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo
Insa Geffers et al.
JOURNAL OF CELL BIOLOGY (2007)
Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen
Michele L. Caton et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems
Merritt K. Taylor et al.
DEVELOPMENT (2007)
The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling
Alena Malyukova et al.
CANCER RESEARCH (2007)
Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear
Nicolas Daudet et al.
DEVELOPMENT (2007)
Inhibition of D114-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion
Jeffrey S. Scehnet et al.
BLOOD (2007)
Segmental border is defined by the key transcription factor Mesp2, by means of the suppression of Notch activity
Yumiko Saga
DEVELOPMENTAL DYNAMICS (2007)
Developmental basis of vascular smooth muscle diversity
Mark W. Majesky
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)
Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers
Alena Krejci et al.
GENES & DEVELOPMENT (2007)
The archetypal R90C CADASIL-NOTCH3 mutation retains NOTCH3 function in vivo
Marie Monet et al.
HUMAN MOLECULAR GENETICS (2007)
Structural basis for autoinhibition of Notch
Wendy R. Gordon et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells
Elena Vasyutina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
The Notch signaling pathway in the cnidarian Hydra
Tina Kaesbauer et al.
DEVELOPMENTAL BIOLOGY (2007)
Notch signaling is essential for ventricular chamber development
Joaquin Grego-Bessa et al.
DEVELOPMENTAL CELL (2007)
Delta-like ligand 4 (DII4) is induced by VEGF as a negative regulator of angiogenic sprouting
I. B. Lobov et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
Mats Hellstroem et al.
NATURE (2007)
Notch-1 regulates pulmonary neuroendocrine cell differentiation in cell lines and in transgenic mice
Lin Shan et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2007)
An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation
Frances A. High et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants
Karin Schuster-Gossler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Monitoring Notch1 activity in development: Evidence for a feedback regulatory loop
Gonzalo Del Monte et al.
DEVELOPMENTAL DYNAMICS (2007)
Distinct delta and jagged genes control sequential segregation of pancreatic cell types from precursor pools in zebrafish
E. Zecchin et al.
DEVELOPMENTAL BIOLOGY (2007)
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
Irene Noguera-Troise et al.
NATURE (2006)
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
John Ridgway et al.
NATURE (2006)
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
Teresa Palomero et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Lethal giant discs, a novel C2-domain protein, restricts notch activation during endocytosis
Jennifer L. Childress et al.
CURRENT BIOLOGY (2006)
High levels of Notch signaling down-regulate Numb and Numblike
Gavin Chapman et al.
JOURNAL OF CELL BIOLOGY (2006)
AML1/Runx1 rescues Notch1-null mutation-induced deficiency of para-aortic splanchnopleural hematopoiesis
Masahiro Nakagawa et al.
BLOOD (2006)
Jagged 1 is a β-catenin target gene required for ectopic hair follicle formation in adult epidermis
Soline Estrach et al.
DEVELOPMENT (2006)
Canonical Notch signaling functions as a commitment switch in the epidermal lineage
Cedric Blanpain et al.
GENES & DEVELOPMENT (2006)
Pancreatic regeneration in chronic pancreatitis requires activation of the Notch signaling pathway
Yun Su et al.
JOURNAL OF GASTROINTESTINAL SURGERY (2006)
The conserved C2 domain protein lethal (2) giant discs regulates protein trafficking in Drosophila
Ciara M. Gallagher et al.
DEVELOPMENTAL CELL (2006)
Expression of the notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas
Ilse Rooman et al.
AMERICAN JOURNAL OF PATHOLOGY (2006)
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
Andrew P. Weng et al.
GENES & DEVELOPMENT (2006)
Impaired Notch signaling promotes de novo squamous cell carcinoma formation
Aaron Proweller et al.
CANCER RESEARCH (2006)
Novel missense mutations (p.T596M and p.P1797H) in NOTCH1 in patients with bicuspid aortic valve
SA Mohamed et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex
Takeshi Yoshimatsu et al.
DEVELOPMENT (2006)
Smooth muscle α-actin is a direct target of Notch/CSL
Michela Noseda et al.
CIRCULATION RESEARCH (2006)
The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development
Seungwoon Seo et al.
DEVELOPMENTAL BIOLOGY (2006)
Gamma secretase-mediated notch signaling worsens brain damage and functional outcome in ischemic stroke
TV Arumugam et al.
NATURE MEDICINE (2006)
Ectopic pancreas formation in Hes1-knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas
Akihisa Fukuda et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation
BC Nguyen et al.
GENES & DEVELOPMENT (2006)
Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation
A Miyamoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface
C Kaether et al.
TRAFFIC (2006)
Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear
R Brooker et al.
DEVELOPMENT (2006)
Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA
JJ Wilson et al.
CELL (2006)
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes
Y Nam et al.
CELL (2006)
Notch3 and pre-TCR interaction unveils distinct NF-κB pathways in T-cell development and leukemia
A Vacca et al.
EMBO JOURNAL (2006)
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
HS Phillips et al.
CANCER CELL (2006)
Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors
CY Hu et al.
AMERICAN JOURNAL OF PATHOLOGY (2006)
Target selectivity of vertebrate notch proteins - Collaboration between discrete domains and CSL-binding site architecture determines activation probability
CT Ong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation
XD Wang et al.
DEVELOPMENTAL BIOLOGY (2006)
Aberrant activation of Notch signaling in human breast cancer
S Stylianou et al.
CANCER RESEARCH (2006)
Control of hepatic differentiation by Activin/TGFβ signaling
F Clotman et al.
CELL CYCLE (2006)
PTF1 is an organ-specific and notch-independent basic helix-loop-helix complex containing the mammalian suppressor of hairless (RBP-J) or its paralogue, RBP-L
TM Beres et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas
J Fujikura et al.
CELL METABOLISM (2006)
The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear
Amy E. Kiernan et al.
PLOS GENETICS (2006)
Notch3 ectodomain is a major component of granular osmiophilic material (GOM) in CADASIL
Akira Ishiko et al.
ACTA NEUROPATHOLOGICA (2006)
Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype
DB Sparrow et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2006)
MicroRNA1 influences cardiac differentiation in Drosophila and regulates notch signaling
C Kwon et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Regulation of notch signalling by non-visual β-arrestin
A Mukherjee et al.
NATURE CELL BIOLOGY (2005)
Endocytic control of epithelial polarity and proliferation in Drosophila
H Lu et al.
NATURE CELL BIOLOGY (2005)
Negative feedback loop formed by lunatic fringe and Hes7 controls their oscillatory expression during somitogenesis
J Chen et al.
GENESIS (2005)
Different thresholds of Notch signaling bias human precursor cells toward B-, NK-, monocytic/dendritic-, or T-cell lineage in thymus microenvironment
M De Smedt et al.
BLOOD (2005)
Notch-mediated CBF-1/RBP-Jκ-dependent regulation of human vascular smooth muscle cell phenotype in vitro
D Morrow et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2005)
Hypoxia requires Notch signaling to maintain the undifferentiated cell state
MV Gustafsson et al.
DEVELOPMENTAL CELL (2005)
Upregulation of ASCL1 and inhibition of Notch signaling pathway characterize progressive astrocytoma
K Somasundaram et al.
ONCOGENE (2005)
Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function
NS Patel et al.
CANCER RESEARCH (2005)
The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear
AE Kiernan et al.
DEVELOPMENT (2005)
Hematopoietic stem cell fate is established by the Notch-Runx pathway
CE Burns et al.
GENES & DEVELOPMENT (2005)
High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival
M Reedijk et al.
CANCER RESEARCH (2005)
The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands
E Ladi et al.
JOURNAL OF CELL BIOLOGY (2005)
Mutations in NOTCH1 cause aortic valve disease
V Garg et al.
NATURE (2005)
Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-β signaling
YP Sun et al.
ONCOGENE (2005)
Cardiac stem and progenitor cell biology for regenerative medicine
D Torella et al.
TRENDS IN CARDIOVASCULAR MEDICINE (2005)
Notch signals control the fate of immature progenitor cells in the intestine
S Fre et al.
NATURE (2005)
Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
JH van Es et al.
NATURE (2005)
Complementation of human papillornavirus Type 16 E6 and E7 by Jagged1-specific notch1-phosphatidylinositol 3-kinase signaling involves pleiotropic oncogenic functions independent of CBF1;Su(H);Lag-1 activation
K Veeraraghavalu et al.
JOURNAL OF VIROLOGY (2005)
Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity
LR You et al.
NATURE (2005)
Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers
N Haruki et al.
CANCER RESEARCH (2005)
Essential role of endothelial Notch1 in angiogenesis
FP Limbourg et al.
CIRCULATION (2005)
Notch modulates Wnt signalling by associating with Armadillo/β-catenin and regulating its transcriptional activity
P Hayward et al.
DEVELOPMENT (2005)
Notch signaling represses myocardin-induced smooth muscle cell differentiation
A Proweller et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury
GK Michalopoulos et al.
HEPATOLOGY (2005)
Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration
JN Jensen et al.
GASTROENTEROLOGY (2005)
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
IM Conboy et al.
NATURE (2005)
Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system
H Kokubo et al.
DEVELOPMENTAL BIOLOGY (2005)
Bre1 is required for notch signaling and histone modification
S Bray et al.
DEVELOPMENTAL CELL (2005)
Two contrasting roles for Notch activity in chick inner ear development: specification of prosensory patches and lateral inhibition of hair-cell differentiation
N Daudet et al.
DEVELOPMENT (2005)
Functional diversity of notch family genes in fetal lung development
YP Kong et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2004)
The Notch target genes Hey1 and Hey2 are required for embryonic vascular development
A Fischer et al.
GENES & DEVELOPMENT (2004)
Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration
C Köhler et al.
HEPATOLOGY (2004)
Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells
F Itoh et al.
EMBO JOURNAL (2004)
Pathogenic mutations associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy differently affect Jagged1 binding and Notch3 activity via the RBP/JK signaling pathway
A Joutel et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2004)
Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA
RA Kovall et al.
EMBO JOURNAL (2004)
Intramembrane proteotysis: Theme and variations
MS Wolfe et al.
SCIENCE (2004)
Modulation of notch signaling elicits signature tumors and inhibits Hras1-induced oncogenesis in the mouse mammary epithelium
H Kiaris et al.
AMERICAN JOURNAL OF PATHOLOGY (2004)
Notch signaling in Drosophila long-term memory formation
XC Ge et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Monoubiquitination and endocytosis direct γ-secretase cleavage of activated Notch receptor
N Gupta-Rossi et al.
JOURNAL OF CELL BIOLOGY (2004)
Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors
N Tanimizu et al.
JOURNAL OF CELL SCIENCE (2004)
Notch 1 and 3 receptors modulate vascular smooth muscle cell growth, apoptosis and migration via a CBF-1/RBP-Jk dependent pathway
C Sweeney et al.
FASEB JOURNAL (2004)
Molecular regulation of vascular smooth muscle cell differentiation in development and disease
GK Owens et al.
PHYSIOLOGICAL REVIEWS (2004)
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation
LA Timmerman et al.
GENES & DEVELOPMENT (2004)
Conversion of biliary system to pancreatic tissue in Hes1-deficient mice
R Sumazaki et al.
NATURE GENETICS (2004)
Mastermind recruits CycC:CDK8 to phosphorylate the notch ICD and coordinate activation with turnover
CJ Fryer et al.
MOLECULAR CELL (2004)
A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development
BK Hadland et al.
BLOOD (2004)
Notch3 is required for arterial identity and maturation of vascular smooth muscle cells
V Domenga et al.
GENES & DEVELOPMENT (2004)
Involvement of Notch signaling in hippocampal synaptic plasticity
Y Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development
NW Gale et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Interplay between Notch signaling and the homeoprotein Xiro1 is required for neural crest induction in Xenopus embryos
A Glavic et al.
DEVELOPMENT (2004)
Mutated MESP2 causes spondylocostal dysostosis in humans
NV Whittock et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2004)
Transcription factor CHF1/Hey2 regulates neointimal formation in vivo and vascular smooth muscle proliferation and migration in vitro
Y Sakata et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2004)
Modulation of notch processing by γ-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation
J Milano et al.
TOXICOLOGICAL SCIENCES (2004)
Notch1 and Notch2 have opposite effects on embryonal brain tumor growth
X Fan et al.
CANCER RESEARCH (2004)
Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling
S Kamakura et al.
NATURE CELL BIOLOGY (2004)
Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo
K Hozumi et al.
NATURE IMMUNOLOGY (2004)
Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis
S Pece et al.
JOURNAL OF CELL BIOLOGY (2004)
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
LT Krebs et al.
GENES & DEVELOPMENT (2004)
Dosage-sensitive requirement for mouse D114 in artery development
A Duarte et al.
GENES & DEVELOPMENT (2004)
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
AP Weng et al.
SCIENCE (2004)
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells
D Amsen et al.
CELL (2004)
JAGGED1 expression is associated with prostate cancer metastasis and recurrence
S Santagata et al.
CANCER RESEARCH (2004)
Wingless and Notch signaling provide cell survival cues and control cell proliferation during wing development
AJ Giraldez et al.
DEVELOPMENT (2003)
Functional notch signaling is required for BMP4-induced inhibition of myogenic differentiation
C Dahlqvist et al.
DEVELOPMENT (2003)
Notch-mediated restoration of regenerative potential to aged muscle
IM Conboy et al.
SCIENCE (2003)
Cross-talk between the Notch and TGF-β signaling pathways mediated by interaction of the Notch intracellular domain with Smad3
A Blokzijl et al.
JOURNAL OF CELL BIOLOGY (2003)
Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes
E Anastasi et al.
JOURNAL OF IMMUNOLOGY (2003)
neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions
T Sasamura et al.
DEVELOPMENT (2003)
HRT1 modulates vascular smooth muscle cell proliferation and apoptosis
WL Wang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Learning and memory deficits in Notch mutant mice
RM Costa et al.
CURRENT BIOLOGY (2003)
Oscillations, clocks and segmentation
Y Bessho et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2003)
Delta-Notch signaling regulates oligodendrocyte specification
HC Park et al.
DEVELOPMENT (2003)
Evaluation of diagnostic NOTCH3 immunostaining in CADASIL
SAJL Oberstein et al.
ACTA NEUROPATHOLOGICA (2003)
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
H Gerhardt et al.
JOURNAL OF CELL BIOLOGY (2003)
Mammalian numb proteins promote notch1 receptor ubiquitination and degradation of the notch1 intracellular domain
MA McGill et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Structural requirements for assembly of the CSL•Intracellular Notch1•Mastermind-like 1 transcriptional activation complex
Y Nam et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Notch steers Drosophila ISNb motor axons by regulating the Abl signaling pathway
D Crowner et al.
CURRENT BIOLOGY (2003)
Medical progress: Heart failure
M Jessup et al.
NEW ENGLAND JOURNAL OF MEDICINE (2003)
Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development
T Saito et al.
IMMUNITY (2003)
Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways
SL Shi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Constitutive activation of Notch3 inhibits terminal epithelial differentiation in lungs of transgenic mice
TP Dang et al.
ONCOGENE (2003)
Notch1 functions as a tumor suppressor in mouse skin
M Nicolas et al.
NATURE GENETICS (2003)
Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway
K Kuroda et al.
IMMUNITY (2003)
Characterization of Notch3-deficient mice: Normal embryonic development and absence of genetic interactions with a Notch1 mutation
LT Krebs et al.
GENESIS (2003)
Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by delta
M Itoh et al.
DEVELOPMENTAL CELL (2003)
Regulation of notch signaling by O-linked fucose
T Okajima et al.
CELL (2002)
Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans
DD Shaye et al.
NATURE (2002)
Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro
TM Schmitt et al.
IMMUNITY (2002)
p300 and PCA act cooperatively to mediate transcriptional activation from chromatin templates by Notch intracellular domains in vitro
AE Wallberg et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression
KL Taylor et al.
MICROVASCULAR RESEARCH (2002)
SHARP is a novel component of the Notch/RBP-Jκ signalling pathway
F Oswald et al.
EMBO JOURNAL (2002)
Mouse gridlock:: No aortic coarctation or deficiency, but fatal cardiac defects in Hey2 -/- mice
M Gessler et al.
CURRENT BIOLOGY (2002)
Disruption of segmental neural crest migration and ephrin expression in Delta-1 null mice
ME De Bellard et al.
DEVELOPMENTAL BIOLOGY (2002)
The regulation of notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis
IM Conboy et al.
DEVELOPMENTAL CELL (2002)
The endocytic protein α-adaptin is required for numb-mediated asymmetric cell division in Drosophila
D Berdnik et al.
DEVELOPMENTAL CELL (2002)
Mouse notch 3 expression in the pre- and postnatal brain: Relationship to the stroke and dementia syndrome CADASIL
N Prakash et al.
EXPERIMENTAL CELL RESEARCH (2002)
Delta/Notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like ReDeat-cont ining protein T ryeted to dendrites of developing and adult central nervous system neurons
M Eiraku et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
sonic hedgehog and vascular endothelial growth factor act upstream of the notch pathway during arterial endothelial differentiation
ND Lawson et al.
DEVELOPMENTAL CELL (2002)
Glycogen synthase kinase-3β modulates notch signaling and stability
DR Foltz et al.
CURRENT BIOLOGY (2002)
Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision
H Han et al.
INTERNATIONAL IMMUNOLOGY (2002)
Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype
A Jögi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Segmentation defects of notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice
N Zhang et al.
GENESIS (2002)
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells
K Tanigakik et al.
NATURE IMMUNOLOGY (2002)
Notch signaling induces rapid degradation of achaete-scute homolog 1
V Sriuranpong et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Skin biopsy immunostaining with a Notch3 monoclonal antibody for CADASIL diagnosis
A Joutel et al.
LANCET (2001)
EBNA2 and Notch signalling in Epstein-Barr virus mediated immortalization of B lymphocytes
U Zimber-Strobl et al.
SEMINARS IN CANCER BIOLOGY (2001)
neuralized encodes a peripheral membrane protein involved in Delta signaling and endocytosis
E Pavlopoulos et al.
DEVELOPMENTAL CELL (2001)
Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of Delta
EC Lai et al.
DEVELOPMENTAL CELL (2001)
Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling
GA Deblandre et al.
DEVELOPMENTAL CELL (2001)
SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation
GY Wu et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Neuralized functions as an E3 ubiquitin ligase during Drosophila development
E Yeh et al.
CURRENT BIOLOGY (2001)
Dynamic expression and essential functions of Hes7 in somite segmentation
Y Bessho et al.
GENES & DEVELOPMENT (2001)
The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian sel-10 homolog
C Öberg et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor
N Gupta-Rossi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
A Rangarajan et al.
EMBO JOURNAL (2001)
p48 subunit of mouse PTF1 binds to RBP-Jκ/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos
J Obata et al.
GENES TO CELLS (2001)
The Notch ligand Jagged1 is required for inner ear sensory development
AE Kiernan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Activation of the Notch-regulated transcription factor CBF1/RBP-Jκ through the 13SE1A oncoprotein
S Ansieau et al.
GENES & DEVELOPMENT (2001)
Hes7:: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm
Y Bessho et al.
GENES TO CELLS (2001)
MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors
LZ Wu et al.
NATURE GENETICS (2000)
Notch signalling and the synchronization of the somite segmentation clock
YJ Jiang et al.
NATURE (2000)
Notch/Delta expression in the developing mouse lung
LC Post et al.
MECHANISMS OF DEVELOPMENT (2000)
Notch signaling in the development of the inner ear:: Lessons from Drosophila
M Eddison et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene
ZM Deng et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2000)
Glycosyltransferase activity of fringe modulates notch-delta interactions
K Brückner et al.
NATURE (2000)
Fringe is a glycosyltransferase that modifies Notch
DJ Moloney et al.
NATURE (2000)
SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans
TG Doyle et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Mastermind is a putative activator for Notch
AG Petcherski et al.
CURRENT BIOLOGY (2000)
Notch gene expression during pancreatic organogenesis
E Lammert et al.
MECHANISMS OF DEVELOPMENT (2000)
Transient notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells
SJ Morrison et al.
CELL (2000)
Stimulation of human epidermal differentiation by Delta-Notch signalling at the boundaries of stem-cell clusters
S Lowell et al.
CURRENT BIOLOGY (2000)
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