Journal
JACC-BASIC TO TRANSLATIONAL SCIENCE
Volume 3, Issue 4, Pages 563-572Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacbts.2018.01.014
Keywords
angiogenesis; apoptosis; cytokines; senescence
Categories
Funding
- National Institutes of Health [HL-130193, HL-123346, HL-118462, P30 CA16672]
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In radiation therapy for cancer, the therapeutic ratio represents an optimal balance between tumor control and normal tissue complications. As improvements in the therapeutic arsenal against cancer extend longevity, the importance of late effects of radiation increases, particularly those caused by vascular endothelial injury. Radiation both initiates and accelerates atherosclerosis, leading to vascular events like stroke, coronary artery disease, and peripheral artery disease. increased levels of proinflammatory cytokines in the blood of tong-term survivors of the atomic bomb suggest that radiation evokes a systemic inflammatory state responsible for chronic vascular side effects. In this review, the authors offer an overview of potential mechanisms implicated in radiation-induced vascular injury. Published by Elsevier on behalf of the American College of Cardiology Foundation.
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