Journal
NATURE PLANTS
Volume 4, Issue 8, Pages 586-595Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41477-018-0213-y
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Funding
- NIH [R01-GM043778]
- Howard Hughes Medical Institute
- Gordon and Betty Moore Foundation [GBMF3405]
- ERC [616228-ENDOFUN]
- SNSF [31003A_156261]
- EMBO short-term fellowship
- University of Delaware
- FEBS long-term fellowship
- IEF Marie Curie fellowship
- Swiss National Science Foundation (SNF) [31003A_156261] Funding Source: Swiss National Science Foundation (SNF)
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Changes in gene regulation during differentiation are governed by networks of transcription factors. The Arabidopsis root endodermis is a tractable model to address how transcription factors contribute to differentiation. We used a bottom-up approach to understand the extent to which transcription factors that are required for endodermis differentiation can confer endodermis identity to a non-native cell type. Our results show that the transcription factors SHORTROOT and MYB36 alone have limited ability to induce ectopic endodermal features in the absence of additional cues. The stele-derived signalling peptide CIF2 stabilizes SHORTROOT-induced endodermis identity acquisition. The outcome is a partially impermeable barrier deposited in the subepidermal cell layer, which has a transcriptional signature similar to the endodermis. These results demonstrate that other root cell types can be forced to differentiate into the endodermis and highlight a previously unappreciated role for receptor kinase signalling in maintaining endodermis identity.
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