Journal
NATURAL PRODUCT COMMUNICATIONS
Volume 13, Issue 8, Pages 977-980Publisher
NATURAL PRODUCTS INC
Keywords
Antioxidant; Cyclooxygenase; Cyclooctadiene lignan; C-Methylated flavonoid; Anti-inflammatory; Folk medicine
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Funding
- FAPESP [04/07932-7, 13/07600-3]
- CNPq [474270/2012-2]
- CAPES
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [04/07932-7] Funding Source: FAPESP
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Tea prepared from leaves of Eugenia brasiliensis has been used as a folk medicine in Brazil to alleviate inflammation and pain. In this study, tea and methanolic extract inhibited cyclooxygenase (COX-1 and -2) enzymes and lipid peroxidation (LPO). Therefore, bioassay-guided purification of methanolic extract was carried out and afforded a new lignan (aR,8S,8'R-7,8,7',8'-tetrahydro-8,8'-dimethyl-3,3'-dimethoxy-4,4'-dihydroxy-dibenzocyclooctadiene) and three known C-methylated flavonoids (stropopinin; demethoxymatteucinol; myrigalone G). All isolates at 37.5 mu g/mL inhibited COX enzymes, similar to aspirin and ibuprofen used as controls at 108 and 12 mu g/mL, respectively. Most of the isolates also showed strong LPO inhibition at 5 mu g/mL.
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