Alleviatory effects of hydroalcoholic extract of Brassica oleracea var. botrytis leaves against sodium fluoride induced hepatotoxicity and oxidative stress on male Wistar rats

Fluoride is one of the most common pollutants of potable water. Fluorosis is an endemic and global problem. Excessive intake of fluoride might accumulate and alter the functions of soft tissues including liver. The main objective of the present study was to investigate the alleviatory effects of hydroalcoholic extract of Brassica oleracea var. botrytis (BOB) leaves on sodium fluoride (NaF) induced hepatotoxicity. Thirty-six male Wistar albino rats were divided into six groups of six animals in each. Group I served as the normal control. Group II served as toxic control. Group III, IV, and V served as treatment groups received extract at three doses 100, 200, and 400 mg/kg respectively. Group VI served as plant control received a hydroalcoholic extract of BOB leaves 400 mg/kg. All groups except I, and VI, received NaF (100 ppm) through drinking water for 30 days. After the end of the study, serum profile and lipid peroxidation, reduced glutathione and catalase enzyme levels were measured in homogenates of the liver. The results of the present study suggested that BOB alleviates sodium fluoride-induced hepatotoxicity, probably via its antioxidant activity.