4.7 Article

Fatal Nongroupable Neisseria meningitidis Disease in Vaccinated Patient Receiving Eculizumab

Journal

EMERGING INFECTIOUS DISEASES
Volume 24, Issue 8, Pages 1561-1564

Publisher

CENTERS DISEASE CONTROL
DOI: 10.3201/eid2408.180228

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Funding

  1. National Institute of Allergy and Infectious Diseases, National Institutes of Health [R01 AI046464, R01 AI114701]
  2. Research Facilities Improvement Program grant from National Center for Research Resources, National Institutes of Health [C06 RR016226]

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Patients receiving eculizumab have an increased risk for meningococcal disease, but most reported cases are attributable to encapsulated meningococcal strains. We describe a case in which a nongroupable meningococcal strain, which rarely causes disease in healthy persons, caused fatal disease in an eculizumab recipient despite meningococcal vaccination.

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