Journal
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
Volume 11, Issue -, Pages -Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1756286418789340
Keywords
biomarkers; cerebrovascular disease; inflammation; neuroprotection; stroke; therapeutic targets
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Funding
- Fondo de Investigaciones Sanitarias of the Instituto de Salud Carlos III [PI15/00354]
- European Regional Development Fund, FEDER
- Spanish stroke research network INVICTUS+ [RD16/0019]
- Instituto de Salud Carlos III [IFI17/00012]
- AGAUR [2015 FI_B00952]
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Stroke is the fifth leading cause of death and the most frequent cause of disability worldwide. Currently, stroke diagnosis is based on neuroimaging; therefore, the lack of a rapid tool to diagnose stroke is still a major concern. In addition, therapeutic approaches to combat ischemic stroke are still scarce, since the only approved therapies are directed toward restoring blood flow to the affected brain area. However, due to the reduced time window during which these therapies are effective, few patients benefit from them; therefore, alternative treatments are urgently needed to reduce stroke brain damage in order to improve patients' outcome. The inflammatory response triggered after the ischemic event plays an important role in the progression of stroke; consequently, the study of inflammatory molecules in the acute phase of stroke has attracted increasing interest in recent decades. Here, we provide an overview of the inflammatory processes occurring during ischemic stroke, as well as the potential for these inflammatory molecules to become stroke biomarkers and the possibility that these candidates will become interesting neuroprotective therapeutic targets to be blocked or stimulated in order to modulate inflammation after stroke.
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