Journal
EXCLI JOURNAL
Volume 17, Issue -, Pages 709-720Publisher
EXCLI JOURNAL MANAGING OFFICE
DOI: 10.17179/excli2018-1353
Keywords
Type 2 diabetes mellitus; T2DM; autophagy; retinopathy; cardiomyopathy; nephropathy
Categories
Funding
- Dr. DS Kothari postdoctoral fellowship scheme of UGC, Government of India
Ask authors/readers for more resources
Diabetes mellitus (DM) is an endocrine disorder. In coming decades it will be one of the leading causes of death globally. The key factors in the pathogenesis of diabetes are cellular injuries and disorders of energy metabolism leading to severe diabetic complications. Recent studies have confirmed that autophagy plays a pivotal role in diabetes and its complications. It has been observed that autophagy regulates the normal function of pancreatic beta cells and insulin-target tissues, such as skeletal muscle, liver, and adipose tissue. This review will summarize the regulation of autophagy in diabetes and its complications, and explore how this process would emerge as a potential therapeutic target for diabetes treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available