Journal
INTERNATIONAL NEUROUROLOGY JOURNAL
Volume 22, Issue -, Pages S66-S75Publisher
KOREAN CONTINENCE SOC
DOI: 10.5213/inj.1836154.077
Keywords
Extracellular matrix; Tissue regeneration; Versatile extracellular matrix; Urology
Categories
Funding
- National Research Foundation of Korea [2018R1A6A1A03024940]
- Human Resources Program in Energy Technology of the Korea Institute of Energy Technology Evaluation and Planning [20174010201150]
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Native and artificial extracellular matrices (ECMs) have been widely applied in biomedical fields as one of the most effective components in tissue regeneration. In particular, ECM-based drugs are expected to be applied to treat diseases in organs relevant to urology, because tissue regeneration is particularly important for preventing the recurrence of these diseases. Native ECMs provide a complex in vivo architecture and native physical and mechanical properties that support high biocompatibility. However, the applications of native ECMs are limited due to their tissue-specificity and chemical complexity. Artificial ECMs have been fabricated in an attempt to create a broadly applicable scaffold by using controllable components and a uniform formulation. On the other hands, artificial ECMs fail to mimic the properties of a native ECM; consequently, their applications in tissues are also limited. For that reason, the design of a versatile, hybrid ECM that can be universally applied to various tissues is an emerging area of interest in the biomedical field.
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