Journal
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Volume 19, Issue 39, Pages 26728-26733Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cp05157c
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Funding
- Development of Systems and Technology for Advanced Measurement and Analysis from AMED (The Japan Agency for Medical Research and Development)SENTAN
- ALCA from Japan Science and Technology Agency (JST)
- PREST from Japan Science and Technology Agency (JST)
- Japan Society for the Promotion of Science (JSPS) [16H02280, 15H03542, 15H05422, 16H06042, 15K13263, 16H00885]
- Nakatani Foundation
- Asahi Glass Foundation
- Grants-in-Aid for Scientific Research [16J02319, 15H03542, 16H06042, 15H05422, 16H00885, 17H02076, 15K13263] Funding Source: KAKEN
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Local cell-membrane permeability and ionic strength are important factors for maintaining the functions of cells. Here, we measured the spatial electrochemical and ion concentration profile near the sample surface with nanoscale resolution using scanning electrochemical microscopy (SECM) combined with scanning ion-conductance microscopy (SICM). The ion current feedback system is an effective way to control probe-sample distance without contact and monitor the kinetic effect of mediator regeneration and the chemical concentration profile. For demonstrating 3D electrochemical and ion concentration mapping, we evaluated the reaction rate of electrochemical mediator regeneration on an unbiased conductor and visualized inhomogeneous permeability and the ion concentration 3D profile on a single fixed adipocyte cell surface.
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