Journal
FEMS MICROBIOLOGY LETTERS
Volume 365, Issue 11, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/femsle/fny094
Keywords
protein secretion; ABC transporter; secretion sequence; RTX toxin
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Funding
- DFG through CRC 1208
- Manchot Graduate School Molecules of Infections III
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Type I secretion systems are widespread in Gram-negative bacteria and mediate the one-step translocation of a large variety of proteins serving for diverse purposes, including nutrient acquisition or bacterial virulence. Common to most substrates of type I secretion systems is the presence of a C-terminal secretion sequence that is not cleaved during or after translocation. Furthermore, these protein secretion nanomachineries are always composed of an ABC transporter, a membrane fusion protein, both located in the inner bacterial membrane, and a protein of the outer membrane. These three membrane proteins transiently form a `tunnel channel' across the periplasmic space in the presence of the substrate. Here we summarize the recent findings with respect to structure, function and application of type I secretion systems.
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