Journal
ACS APPLIED BIO MATERIALS
Volume 1, Issue 2, Pages 210-215Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.8b00085
Keywords
human embryonic stem cells; two-dimensional (2D) materials; current-voltage measurements; molecular dynamics (MD) simulations; nano-scale; chemical design
Funding
- Ministry of Education (Singapore)
- Agency of Science, Technology and Research (A*STAR)
- NTU
- SUTD
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We observed a unique bioelectric signal of human embryonic stem cells using direct current-voltage measurements facilitated by few-layered 2D-MoS2 sheets. A 1.828 mA cell signal was achieved (2 orders of magnitude higher than previous electrical-based detection methods) as well as multiple cell reading cycles demonstrating I similar to 1.9 mA. Native stem cell proliferation, viability, and pluripotency were preserved. Molecular dynamics simulations elucidated the origin of the 2D-MoS2 sheet-assisted increase in current flow. This paves the way for the development of a broadly applicable, fast, and damage-free stem cell detection method capable of identifying pluripotency with virtually any complementary-metal-oxide-semiconductor circuits.
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