Journal
FRONTIERS IN CARDIOVASCULAR MEDICINE
Volume 5, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2018.00113
Keywords
microparticle; atherosclerosis; vascular remodeling; diagnostic; platelet; endothelial cell; monocyte
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Funding
- European Union [722609]
- Netherlands Foundation for Scientific Research [ZonMW VIDI 016.126.358]
- Landsteiner Foundation for Blood Transfusion Research (LSBR) [1638]
- Deutsche Forschungsgemeinschaft [SFB1123/A2]
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The field of extracellular vesicles (EV) is rapidly expanding, also within cardiovascular diseases. Besides their exciting roles in cell-to-cell communication, EV have the potential to serve as excellent biomarkers, since their counts, content, and origin might provide useful information about the pathophysiology of cardiovascular disorders. Various studies have already indicated associations of EV counts and content with cardiovascular diseases. However, EV research is complicated by several factors, most notably the small size of EV. In this review, the advantages and drawbacks of EV-related methods and applications as biomarkers are highlighted.
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