Journal
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY
Volume 3, Issue 1, Pages 3-19Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.synbio.2017.12.001
Keywords
Biosurfactant; Glycolipids biosynthesis; Glycosyl/acyl transferases; Glycosides; Physiological roles; Lipid biotechnology
Categories
Funding
- United States Department of Energy - Chicago (DoE-Chicago) [DE-SC0008744]
- Natural Sciences and Engineering Research Council of Canada (NSERC) [PDF-488195-2016]
- US DoE grant [DE-SC0008744]
- U.S. Department of Energy (DOE) [DE-SC0008744] Funding Source: U.S. Department of Energy (DOE)
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Glycosylated lipids (GLs) are added-value lipid derivatives of great potential. Besides their interesting surface activities that qualify many of them to act as excellent ecological detergents, they have diverse biological activities with promising biomedical and cosmeceutical applications. Glycolipids, especially those of microbial origin, have interesting antimicrobial, anticancer, antiparasitic as well as immunomodulatory activities. Nonetheless, GLs are hardly accessing the market because of their high cost of production. We believe that experience of metabolic engineering (ME) of microbial lipids for biofuel production can now be harnessed towards a successful synthesis of microbial GLs for biomedical and other applications. This review presents chemical groups of bacterial and fungal GLs, their biological activities, their general biosynthetic pathways and an insight on ME strategies for their production. (c) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co.
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