4.1 Article

Overview of enterolactone biological properties and total synthesis

Journal

ARKIVOC
Volume -, Issue -, Pages 76-93

Publisher

ARKAT USA INC
DOI: 10.24820/ark.5550190.p010.451

Keywords

Lignan; enterolactone; estrogen; enantioselective synthesis

Funding

  1. NIH [GM-54656]
  2. North Dakota State University

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Lignans are a class of compounds found in plants, especially fiber-rich foods such as flax seeds, whole grains, berries and vegetables. A diet rich in lignans is believed to be protective against cancer, inflammation, viral infection, stroke, and cardiovascular diseases. Enterolactone, a mammalian lignan, has been investigated extensively due to its potential therapeutic properties. A variety of approaches to synthesize enterolactone have been reported. This account summarizes some of the biological studies and reported syntheses of enterolactone found in literature. [GRAPHICS] .

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