Journal
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
Volume 19, Issue -, Pages 140-152Publisher
ELSEVIER
DOI: 10.1016/j.pdpdt.2017.06.010
Keywords
Photodynamic therapy; Cosmetic; Dermatology
Categories
Funding
- West China Hospital of Sichuan University
- US NIH [R01A1050875, R21A1121700]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI050875, R21AI121700] Funding Source: NIH RePORTER
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Photodynamic therapy (PDT) employs a photosensitizer (PS) and visible light in the presence of oxygen, leading to production of cytotoxic reactive oxygen species, which can damage the cellular organelles and cause cell death. In dermatology, PDT has usually taken the form of topical application of a precursor in the heme biosynthesis pathway, called 5-aminolevulinic acid (or its methyl ester), so that an active PS, protoporphyrin IX accumulates in the skin. As PDT enhances dermal remodeling and resolves chronic inflamation, it has been used to treat cutaneous disorders include actinic keratoses, acne, viral warts, skin rejuvenation, psoriasis, localized scleroderma, some non-melanoma skin cancers and port-wine stains. Efforts are still needed to mitigate the side effects (principally pain) and improve the overall procedure.
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