Synthesis and bioactivity evaluation of new phenyl N,N-phenylphosphorodiamidates

A series of new biologically active phenyl N,N-phenyl phosphorodiamidates were synthesized by reacting phenyl phenylphosphoramidochoridate with various amines. All the newly synthesized compounds 3a-j were tested for their antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydrogen peroxide (H2O2) and nitric oxide (NO) methods. In all the three methods the compounds 3c (phenyl N-(6-methoxy-1,3-benzothiazol-2-yl)-N-phenyl-phosphorodiamidate) and 3e (phenyl N-(5-ethyl-1,3,4-thiadiazol-2-yl)-N-phenylphosphorodiamidate) showed good radical scavenging activity.