Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 372, Issue 1715, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rstb.2016.0413
Keywords
cortical plasticity; synaptic scaling; LTP; LTD; negative feedback; disinhibition
Categories
Funding
- MRC [MR/N003896/1] Funding Source: UKRI
- Medical Research Council [MR/N003896/1] Funding Source: Medline
- NEI NIH HHS [R01 EY025174, R01 EY002874] Funding Source: Medline
- Medical Research Council [MR/N003896/1] Funding Source: researchfish
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Hebbian plasticity is widely considered to be the mechanism by which information can be coded and retained in neurons in the brain. Homeostatic plasticity moves the neuron back towards its original state following a perturbation, including perturbations produced by Hebbian plasticity. How then does homeostatic plasticity avoid erasing the Hebbian coded information? To understand how plasticity works in the brain, and therefore to understand learning, memory, sensory adaptation, development and recovery from injury, requires development of a theory of plasticity that integrates both forms of plasticity into a whole. In April 2016, a group of computational and experimental neuroscientists met in London at a discussion meeting hosted by the Royal Society to identify the critical questions in the field and to frame the research agenda for the next steps. Here, we provide a brief introduction to the papers arising from the meeting and highlight some of the themes to have emerged from the discussions. This article is part of the themed issue 'Integrating Hebbian and homeostatic plasticity'.
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