Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 372, Issue 1735, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rstb.2016.0419
Keywords
composome; origin of life; protocell; RNA world
Categories
Funding
- Engineering and Physical Sciences Research Council [EPSRC EP/F500351/1, EP/I017909/1, EP/K038656/1]
- European Molecular Biology Organization and Marie Curie Actions [ALTF-1455-2015]
- Leverhulme Trust
- bgc3
- Engineering and Physical Sciences Research Council [EP/I017909/1, EP/K038656/1] Funding Source: researchfish
- EPSRC [EP/I017909/1, EP/K038656/1] Funding Source: UKRI
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Here we develop a computational model that examines one of the first major biological innovations-the origin of heredity in simple protocells. The model assumes that the earliest protocells were autotrophic, producing organic matter from CO2 and H-2. Carbon fixation was facilitated by geologically sustained proton gradients across fatty acid membranes, via iron-sulfur nanocrystals lodged within the membranes. Thermodynamic models suggest that organics formed this way should include amino acids and fatty acids. We assume that fatty acids partition to the membrane. Some hydrophobic amino acids chelate FeS nanocrystals, producing three positive feedbacks: (i) an increase in catalytic surface area; (ii) partitioning of FeS nanocrystals to the membrane; and (iii) a proton-motive active site for carbon fixing that mimics the enzyme Ech. These positive feedbacks enable the fastest-growing protocells to dominate the early ecosystem through a simple form of heredity. We propose that as new organics are produced inside the protocells, the localized high-energy environment is more likely to form ribonucleotides, linking RNA replication to its ability to drive protocell growth from the beginning. Our novel conceptualization sets out conditions under which protocell heredity and competition could arise, and points to where crucial experimental work is required. This article is part of the themed issue 'Process and pattern in innovations from cells to societies'.
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