Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 372, Issue 1732, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rstb.2016.0265
Keywords
tumour virus; next-generation sequencing; virus integration
Categories
Funding
- ALF Foundation at Sahlgrenska University Hospital
- Knut and Alice Wallenberg Foundation
- Swedish Foundation for Strategic Research
- Swedish Medical Research Council
- Swedish Cancer Society
- Ake Wiberg foundation
- Region Vastra Gotaland
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With the advent of massively parallel sequencing, oncogenic viruses in tumours can now be detected in an unbiased and comprehensive manner. Additionally, new viruses or strains can be discovered based on sequence similarity with known viruses. Using this approach, the causative agent for Merkel cell carcinoma was identified. Subsequent studies using data from large collections of tumours have confirmed models built during decades of hypothesis-driven and low-throughput research, and a more detailed and comprehensive description of virus-tumour associations have emerged. Notably, large cohorts and high sequencing depth, in combination with newly developed bioinformatical techniques, have made it possible to rule out several suggested virus-tumour associations with a high degree of confidence. In this review we discuss possibilities, limitations and insights gained from using massively parallel sequencing to characterize tumours with viral content, with emphasis on detection of viral sequences and genomic integration events. This article is part of the themed issue 'Human oncogenic viruses'.
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