Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 372, Issue 1731, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rstb.2016.0285
Keywords
DNA double-strand break (DSB); DSB signalling; DSB repair; chromatin remodellers; SMARCA; CHD
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Funding
- Dutch Cancer Society (KWF)
- European Research Council (ERC)
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Proper signalling and repair of DNA double-strand breaks (DSB) is critical to prevent genome instability and diseases such as cancer. The packaging of DNA into chromatin, however, has evolved as a mere obstacle to these DSB responses. Posttranslational modifications and ATP-dependent chromatin remodelling help to overcome this barrier by modulating nucleosome structures and allow signalling and repair machineries access to DSBs in chromatin. Here we recap our current knowledge on how ATP-dependent SMARCA-and CHD-type chromatin remodellers alter chromatin structure during the signalling and repair of DSBs and discuss how their dysfunction impacts genome stability and human disease. This article is part of the themed issue 'Chromatin modifiers and remodellers in DNA repair and signalling'.
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