Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 372, Issue 1726, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rstb.2016.0217
Keywords
Bcl-2; MOMP; mitochondrial fragmentation; cristae remodelling; membrane curvature
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Funding
- DFG [FOR2036]
- ERC [8309966]
- Government of the Basque Country
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The permeabilization of the mitochondrial outer membrane by Bax and Bak during apoptosis is considered a key step and a point of no return in the signalling pathway. It is always closely related to the reorganization of mitochondrial cristae that frees cytochrome c to the intermembrane space and to massive mitochondrial fragmentation mediated by the dynamin-like protein Drp1. Despite multiple evidence in favour of a functional link between these processes, the molecular mechanisms that connect them and their relevance for efficient apoptosis signalling remain obscure. In this review, we discuss recent progress on our understanding of how Bax forms pores in the context of Drp1-stabilized signalling platforms at apoptotic foci in mitochondria. This article is part of the themed issue 'Membrane pores: from structure and assembly, to medicine and technology'.
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