Journal
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Volume 159, Issue -, Pages 6-11Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2017.06.010
Keywords
Neonatal; Delta 9-THC; PCP; Schizophrenia; Behavior; Mice
Funding
- Sumitomo Dainippon
- Sunovion
- Janssen
- Novartis
- ACADIA
- Ferrosan
- Roche
- Takeda
- Pfizer
- Eli Lilly
- EnVivo
- Reviva
- Alkermes
- Astellas
- Jazz
- Solvay
- SureGene
- Bristol Myers Squibb
Ask authors/readers for more resources
The clinical onset of schizophrenia often coincides with cannabis use in adolescents and young adults. However, the neurobiological consequences of this co-morbidity are not well understood. In this study, we examined the effects of Delta 9-THC exposure during early adulthood on schizophrenia-related behaviors using a developmental mouse model of schizophrenia. Phencyclidine (PCP) or saline was administered once in neonatal mice (at P7; 10 mg/kg). In turn, Delta 9-THC or saline was administered sub-acutely later in life to cohorts of animals who had received either PCP or saline (P55-80, 5 mg/kg). Mice who were administered PCP alone displayed behavioral changes in the Morris water waze (MWM) and pre-pulse inhibition (PPI) task paradigm that were consistent with schizophrenia-related phenotypes, but not in the locomotor activity or novel object recognition (NOR) task paradigms. Mice who were administered PCP and then received Delta 9-THC later in life displayed behavioral changes in the locomotor activity paradigm (p < 0.001) that was consistent with a schizophrenia-related phenotype, as well as potentiated changes in the NOR (p < 0.01) and MWM (p < 0.05) paradigms as compared to mice that received PCP alone. Decreased cortical receptor expression of NMDA receptor 1 subunit (NR1) was observed in mice that received PCP and PCP + Delta 9-THC, while mice that received Delta 9-THC and PCP + Delta 9-THC displayed decreases in CB1 receptor expression. These findings suggest that administration of Delta 9-THC during the early adulthood can potentiate the development of schizophrenia-related behavioral phenotypes induced by neonatal exposure to PCP in mice.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available