Journal
PHARMACOLOGICAL RESEARCH
Volume 119, Issue -, Pages 118-127Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2017.01.009
Keywords
Autophagy; Metals; Calcium; Iron; Copper
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Funding
- Sydney Medical School
- Cure Cancer Australia
- NHMRC [1062607]
- National Breast Cancer Foundation
- Avner Pancreatic Cancer Foundation
- National Breast Cancer Foundation [PS-16-030] Funding Source: researchfish
- National Health and Medical Research Council of Australia [1062607] Funding Source: NHMRC
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Autophagy is an evolutionary conserved cellular catabolic degradation process in response to stress which involves lysosomal degradation of unnecessary or damaged organelles and misfolded proteins. This is primarily a pro-survival pathway providing the cell with essential nutrients during stressful conditions. There are number of essential metal ions, which are required for normal physiological functioning of cells. Studies have shown that autophagy can be regulated by cellular metal ion concentrations. On the other hand, autophagy is also shown to regulate intracellular levels of certain metal ions. This review discusses recent advances in the research examining the role of metal ions in the autophagic pathway. (C) 2017 Elsevier Ltd. All rights reserved.
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