Journal
PHARMACOGENOMICS
Volume 18, Issue 17, Pages 1575-1587Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/pgs-2017-0105
Keywords
ADME; Croatia; CYP2B6; gypsy; isolate; pharmacogenetics
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Funding
- Croatian Science Foundation [HRZZ-IP-2014-09-4454]
- Croatian Ministry of Science, Education and Sports [MSES 196-1962766-2747, 196-1962766-2763]
- Nutricia Research Foundation [2012-36/2013-E7]
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Aim: To determine variation of CYP2B6 gene within the genetically specific Croatian Roma (Gypsy) population originating from India and to examine it in the worldwide perspective. Materials & methods: Seven SNP loci (rs12721655, rs2279343, rs28399499, rs34097093, rs3745274, rs7260329 and rs8192709) were genotyped in 439 subjects using Kompetitive Allele Specific PCR (KASP) method. Results: The Croatian Roma took an outlying position in CYP2B6 variation from the worldwide perspective mainly due to their exceptionally high minor allele frequency (MAF) for rs8192709 (12.8%), and lower for rs2279343 (21.1%) compared with south Asian populations. Conclusion: This study provides the first data of several CYP2B6 polymorphisms in Roma population and indicates the need for systematic investigation of the most important pharmacogenes' variants in this large, transnationally isolated population worldwide.
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