Journal
PHARMACOGENOMICS
Volume 18, Issue 4, Pages 369-379Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/pgs-2016-0179
Keywords
CYP3A4; genetic polymorphism; Han Chinese population; novel allelic-variants
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Funding
- National Natural Science Foundation of China [31371280]
- National Health and Family Planning Commission of the People's Republic of China [201302008]
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Aim: To systematically investigate the genetic polymorphisms of the CYP3A4 gene in a Han Chinese population. Materials & methods: The promoter and exons of CYP3A4 gene in 1114 unrelated, healthy Han Chinese subjects were amplified and genotyped by direct sequencing. Results: In total, five previously reported alleles (*1G, * 4, * 5, *18B and * 23) were detected, of which one allele (*23) was reported for the first time in Han Chinese population. Additionally, seven novel exonic variants were also identified and designated as new alleles CYP3A4* 28-*34. Conclusion: This study provides the most comprehensive data of CYP3A4 polymorphisms in Han Chinese population and detects the largest number of novel CYP3A4 alleles in one ethnic group.
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