Journal
PHARMACEUTICAL CHEMISTRY JOURNAL
Volume 51, Issue 4, Pages 307-311Publisher
SPRINGER
DOI: 10.1007/s11094-017-1604-5
Keywords
freeze drying; excipients; lyophilizate structure; drying regime; liposomes
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Lyophilization (freeze drying) is among the most effective methods used to stabilize drugs and increase their shelf life. It is influenced by many factors, the most important of which are the properties of the parent drug substance and the excipients and the freezing and drying conditions. This review considers in detail the excipients used in lyophilized dosage forms and gives examples of sublimation regimes used for the lyophilization of some antitumor drugs.
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