Journal
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Volume 470, Issue 5, Pages 839-849Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00424-017-2089-5
Keywords
Thermosensation; C. elegans; AFD; Receptor guanylyl cyclases; Phosphodiesterases; Adaptation
Categories
Funding
- NIH [R35 GM22463, P01 GM103770, R01 NS047715]
- Mathers Foundation
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R35GM122463, P01GM103770] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS047715] Funding Source: NIH RePORTER
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The nematode C. elegans exhibits complex thermal experience-dependent navigation behaviors in response to environmental temperature changes of as little as 0.01 degrees C over a > 10 degrees C temperature range. The remarkable thermosensory abilities of this animal are mediated primarily via the single pair of AFD sensory neurons in its head. In this review, we describe the contributions of AFD to thermosensory behaviors and temperature-dependent regulation of organismal physiology. We also discuss the mechanisms that enable this neuron type to adapt to recent temperature experience and to exhibit extraordinary thermosensitivity over a wide dynamic range.
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