Journal
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
Volume 141, Issue -, Pages 18-22Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.pestbp.2016.10.006
Keywords
2,4-dichlorophenoxyacetic acid; Toxicity; Testis; Oxidative stress; Apoptosis
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Funding
- National Natural Science Foundation of China [81060056, 81560248]
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The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is used worldwide. It has been associated with a variety of toxicities in rodents. In this study, male mice were orally administered 2,4-D at 50, 100 or 200 mg/kg/day to investigate testicular toxicity and the possible mechanisms of action. Exposure to 2,4-D at high concentrations (100 and 200 mg/kg/day) for 14 consecutive days caused spermatogenic disruption and seminiferous epithelial destruction. Furthermore, 2,4-D administration (100 and 200 mg/kg/day) increased the formation of the lipid per oxidation product malondialdehyde and decreased activities of the antioxidant enzymes superoxide dismutase and catalase in the testis. Moreover, 2,4-D exposure up-regulated the expression of p53 and Bax protein and down-regulated the expression of Bcl-2 protein in the testis. These results demonstrate that oxidative stress and apoptosis may be involved in testicular toxicity induced by high concentrations of 2,4-D in mice. (C) 2016 Elsevier Inc. All rights reserved.
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