Journal
PERSONALIZED MEDICINE
Volume 14, Issue 3, Pages 271-278Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/pme-2016-0107
Keywords
CYP4B1-PS1-001; diabetic kidney disease; diabetic nephropathy; epigenetics; lnc-MGC; lncRNA; MALAT1; MIAT; PVT1; siRNA
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Diabetic kidney disease is a progressive disorder that develops secondary to diabetes. Current strategies for the clinical management of the disease can delay its onset and prevent progression, yet a significant proportion of patients still develop renal failure. The need for more advanced pharmaceuticals is therefore critical for improved treatment strategies. Recent studies support a role for long noncoding RNAs (lncRNAs) in the pathogenesis of human disease. Here we review recent experimental results linking lncRNAs with diabetic kidney disease. A better understanding of the regulatory role that lncRNAs play in the development of diabetic kidney disease may lead to identification of novel targets for therapeutic intervention.
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