Journal
PEDIATRIC RESEARCH
Volume 82, Issue 1, Pages 36-46Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/pr.2017.96
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Funding
- British Heart Foundation [FS/11/65/28865]
- National Institute for Health Research Oxford Biomedical Research Centre
- Oxford British Heart Foundation Centre for Research Excellence
- Wellcome Trust [099973/Z/12/Z]
- Royal Society [099973/Z/12/Z]
- Wellcome Trust [099973/Z/12/Z] Funding Source: Wellcome Trust
- British Heart Foundation [PG/13/58/30397, FS/11/65/28865] Funding Source: researchfish
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BACKGROUND: Adults born very preterm have increased cardiac mass and reduced function. We investigated whether a hypertrophic phenomenon occurs in later preterm infants and when this occurs during early development. METHODS: Cardiac ultrasound was performed on 392 infants (33% preterm at mean gestation 34 2 weeks). Scans were performed during fetal development in 137, at birth and 3 months of postnatal age in 200, and during both fetal and postnatal development in 55. Cardiac morphology and function was quantified and computational models created to identify geometric changes. RESULTS: At birth, preterm offspring had reduced cardiac mass and volume relative to body size with a more globular heart. By 3 months, ventricular shape had normalized but both left and right ventricular mass relative to body size were significantly higher than expected for postmenstrual age (left 57.8 +/- 41.9 vs. 27.3 +/- 29.4%, P < 0.001; right 39.3 +/- 38.1 vs. 16.6 +/- 40.8, P = 0.002). Greater changes were associated with lower gestational age at birth (left P < 0.001; right P = 0.001). CONCLUSION: Preterm offspring, including those born in late gestation, have a disproportionate increase in ventricular mass from birth up to 3 months of postnatal age. These differences were not present before birth. Early postnatal development may provide a window for interventions relevant to long-term cardiovascular health.
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