Journal
PEDIATRIC NEPHROLOGY
Volume 33, Issue 5, Pages 789-798Publisher
SPRINGER
DOI: 10.1007/s00467-017-3684-6
Keywords
Cachexia; Protein energy wasting; Muscle wasting; Chronic kidney disease; Children
Categories
Funding
- NIH [U01 DK-03012, R24HD050837]
- [CAPES 2746-15-8]
- [FAPEMIG PPM-00228-15]
Ask authors/readers for more resources
Loss of lean body mass is a relevant component of the cachexia, or protein energy wasting (PEW), syndrome. Reduced muscle mass seems to be the most solid criterion for the presence of cachexia/PEW in patients with chronic kidney disease (CKD), and those with greater muscle mass loss have a higher risk of death. Children with CKD have many risk factors for lean mass and muscle wasting, including poor appetite, inflammation, growth hormone resistance, and metabolic acidosis. Mortality risks in patients with CKD increases as body mass index (BMI) and weight decreases. However, data regarding cachexia/PEW and muscle wasting in children with CKD is scarce due to lack of consensus in diagnostic criteria and an appropriate investigative methodology. Further research is urgently needed to address this important complication in the pediatric CKD setting, which may have fundamental impact on clinical outcomes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available