Journal
BIOACTIVE MATERIALS
Volume 3, Issue 2, Pages 174-185Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2018.01.003
Keywords
In vitro; Flow conditions; Degradation products; Cell culture conditions
Funding
- China Scholarship Council (CSC)
- Helmholtz Virtual Institute In vivo studies of biodegradable magnesium based implant materials (MetBioMat) [VH-VI-523]
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This review focusses on the application of physiological conditions for the mechanistic understanding of magnesium degradation. Despite the undisputed relevance of simplified laboratory setups for alloy screening purposes, realistic and predictive in vitro setups are needed. Due to the complexity of these systems, the review gives an overview about technical measures, defines some caveats and can be used as a guideline for the establishment of harmonized laboratory approaches. (c) 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
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