Journal
PEDIATRIC BLOOD & CANCER
Volume 65, Issue 2, Pages -Publisher
WILEY
DOI: 10.1002/pbc.26861
Keywords
adolescents and young adults; brain tumor; glioma; pediatric
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Adolescents and young adults (AYA) comprise a specific group of oncology patients with a distinct biological and epidemiological spectrum of central nervous system neoplasms. It has been well documented that they differ clinically, especially in relation to prognosis and chemotherapy tolerance; however, the underlying reasons for this are unclear. Recent advances in the genomics of both childhood and adult brain tumors have provided new explanations and insights into the previously described age-dependent heterogeneity. Herein, we summarize the current state of the AYA population in neuro-oncology, specifically how biological advances can help personalize therapy for this unique group of patients.
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