Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 5, Issue 4, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2018.1458016
Keywords
cathepsin; ABL1; ABL2; Abl; Arg; ETS1; SP1; NF-kappa B; RELA; cysteine cathepsins
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Funding
- HHS / NIH / National Cancer Institute (NCI)
- NIH [R01CA116784, R01CA166499]
- Markey Cancer Foundation Women Strong Award
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Metastatic melanoma remains incurable for many due to its aggressive nature. Secreted cathepsins promote metastasis by cleaving matrix and activating pro-invasive proteases. We reported that ABL kinases induce cathepsin secretion and subsequent metastasis by activating ETS1, SP1, and RELA pathways, indicating that ABL inhibitors may serve as novel anti-cathepsin agents.
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