Journal
REPRODUCTIVE MEDICINE AND BIOLOGY
Volume 17, Issue 4, Pages 481-486Publisher
WILEY
DOI: 10.1002/rmb2.12229
Keywords
eight-hydroxydeoxyguanosine; follicular fluid; glutathione; in vitro fertilization; oxidative stress
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Purpose Antioxidant status and oxidative stress markers in human follicular fluid (FF) surrounding oocytes may be related to the outcomes of in vitro fertilization and embryo transfer (IVF-ET). Therefore, we herein examined the relationship between antioxidant status and oxidative stress markers in FF and the outcomes of IVF-ET. MethodsResultsOne hundred and seventeen infertile women were included in this study. FF was obtained from mature follicles at the time of oocyte retrieval. The total antioxidant capacity (TAC) and total glutathione (GSH), vitamin C, and 8- hydroxy-2-deoxyguanosine (8-OHdG) concentrations were measured. Total GSH levels were lower in patients who had a low fertilization rate after intracytoplasmic sperm injection (ICSI). In addition, 8-OHdG levels were higher in patients who had a low fertilization rate after ICSI and low rate of good quality blastocysts. Total GSH activity was lower in patients with endometriosis. No significant differences were noted in pregnancy outcomes. ConclusionsTotal GSH and 8-OHdG in human FF may be potential markers for fertilization in ART. Also, our findings may suggest that oxidative stress in women with infertility is associated with endometriosis.
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