Journal
PARKINSONISM & RELATED DISORDERS
Volume 43, Issue -, Pages 73-77Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2017.07.015
Keywords
Parkinson's disease; Mild cognitive impairment; PD-CRS; Alternate form; Reliability
Categories
Funding
- FIS grant [PI15/00962]
- Fundacio la Marato de TV3 [2014-2410, 2014-2910]
- Agencia de Gestio damp
- apos
- Ajuts Universitaris i de Recerca [SGR 2014-1203]
- CIBERNED
- CERCA Program of the Catalonian Government
- FEDER
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Introduction: The Parkinson's Disease-Cognitive Rating Scale (PD-CRS) is a valid and reliable instrument to screen for and diagnose mild cognitive impairment in PD (PD-MCI) and to monitor potential outcomes in clinical trials. Although this scale shows adequate sensitivity to change in non-demented PD patients, an alternative form (AF) with proven reliability could minimize practice effects associated with repeated testing. Methods: We selected PD-CRS/AF items following the criteria proposed in the original PD-CRS. We assessed a prospective sample of 75 non-demented PD patients (normal cognition, n = 50; PD-MCI, n = 25) using both tools, administered on two consecutive days, in a randomized order. Results: The PD-CRS/AF showed a high internal consistency (Cronbach's alpha = 0.80). Differences between total mean scores were not significant. Floor/ceiling effects were acceptable. The discriminative power for MCI was high for both tools (area under the curve 0.91; 95% CI, 0.84-0.98 for PD-CRS; 0.88, 95% CI, 0.80-0.96 for PD-CRS/AF). Receiver operating curve analysis showed the optimal cut-off point of the two versions to discriminate PD-MCI from PD-normal cognition was <= 81 (PD-CRS = sensitivity 94%, specificity 73%; PD-CRS/AF = sensitivity 92%, specificity 73%). Conclusions: Our results suggest that the PD-CRS/AF is a valid and reliable instrument to complement the original PD-CRS as an analogous tool for serial cognitive testing for PD patients in clinical practice and cognitive trials. (c) 2017 Published by Elsevier Ld.
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