Journal
JACC-BASIC TO TRANSLATIONAL SCIENCE
Volume 3, Issue 5, Pages 657-671Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacbts.2018.07.007
Keywords
autonomic imbalance; pulmonary arterial hypertension; pulmonary vascular remodeling; vagal nerve stimulation
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Funding
- Japan Agency for Medical Research and Development [18he1102003h0004, 18hm0102041h0003, 18he1902003h0001]
- Japan Society for the Promotion of Science [18K15893]
- Grants-in-Aid for Scientific Research [18K15893] Funding Source: KAKEN
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This study aimed to elucidate the therapeutic effects of electrical vagal nerve stimulation (VNS) on severe pulmonary arterial hypertension in a rat model. In a pathophysiological study, VNS significantly restored autonomic balance, decreased mean pulmonary arterial pressure, attenuated pulmonary vascular remodeling, and preserved right ventricular function. In a survival study, VNS significantly improved the survival rate in both the prevention (VNS from 0 to 5 weeks after a 5U5416 injection) and treatment (VNS from 5 to 10 weeks) protocols. Thus, VNS may serve as a novel therapeutic strategy for pulmonary arterial hypertension. (C) 2018 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
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