Journal
JACC-BASIC TO TRANSLATIONAL SCIENCE
Volume 3, Issue 5, Pages 591-600Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacbts.2018.07.004
Keywords
atrium; risk; surgery; telomere shortening
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Leukocyte telomere shortening reflects stress burdens and has been associated with cardiac events. However, the patient-specific clinical value of telomere assessment remains unknown. Moreover, telomere shortening cannot be inferred from a single telomere length assessment. The authors investigated and developed a novel strategy for gauging leukocyte telomere shortening using autologous cardiac atrial referencing. Using multitissue assessments from 163 patients who underwent cardiovascular surgery, we determined that the cardiac atrium-leukocyte telomere length difference predicted post-operative complexity. This constituted the first evidence that a single-time assessment of telomere dynamics might be salient to acute cardiac care. (C) 2018 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
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